Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men
Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men
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DOI：
10.1017/s0007114510000905
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发表时间：
2010-08-01
影响因子：
3.6
通讯作者：
Shafat, Amir
中科院分区：
文献类型：
--
作者：
Clegg, Miriam;Shafat, Amir
H-2 呼气测试是口盲道通过时间 (OCTT) 测量的理想选择，因为它是非侵入性的且价格低廉。添加到测试餐中的难消化底物会被结肠细菌代谢，从而产生 H2，并在呼气末呼吸中检测到。然而，底物本身可以改变在胃肠道中的通过时间。本研究的目的是比较当液体乳果糖（L-L）、固体乳果糖（L-S）和固体菊粉（IN-S）添加到测试餐中时的 OCTT 和胃排空（GE），并随后检查菊粉是否改变 GE。首先，十名男性志愿者接受了三次测试。志愿者吃的煎饼早餐含有 100 毫克 C-13-辛酸和 12 克 L-L、12 克 L-S 或 12 克 IN-S（按随机顺序）。其次，对 7 名男性志愿者进行了两次测试，膳食中含有 12 克 IN-S 或不含底物 (NO-S)。与 L-S (162.4 (SD 62.6) 分钟) 和菊粉 (292.4 (SD 66.7) 分钟；P = 0.007) 相比，L-L 诱导的 OCTT 最短 (85.3 (SD 42.8) 分钟)。 GE半时和滞后期（L-L：61（SD 9）；L-S：57（SD 10）；IN-S：52（SD 10）分钟；P = 0.005）也受到影响，其中L-L最慢。第三，与 NO-S 相比，菊粉缩短了 GE 滞后期和潜伏期（P < 0.05）。与菊粉相比，乳果糖可加速 OCTT，但延迟 GE。菊粉加速胃排空，但对 GE 半衰期没有影响。由于这些原因，菊粉是 H-2 呼气测试的首选底物。
The H-2 breath test is ideal for orocaecal transit time (OCTT) measurement, as it is non-invasive and inexpensive. Indigestible substrates added to a test meal are metabolised by the colonic bacteria, resulting in the production of H2 which is detected in end-exhalation breath. However, the substrates themselves can alter the transit times in the gastrointestinal tract. The aim of the present study is to compare OCTT and gastric emptying (GE) when lactulose in liquid (L-L), solid lactulose (L-S) and solid inulin (IN-S) are added to a test meal, and subsequently, to examine if inulin alters GE. Firstly, ten male volunteers were tested on three occasions. Volunteers ate a pancake breakfast containing 100 mg of C-13-octanoic acid and either 12 g of L-L, 12 g of L-S or 12 g of IN-S in a randomised order. Secondly, seven male volunteers were tested twice with meals containing either 12 g of IN-S or no substrate (NO-S). L-L induced the shortest OCTT (85.3 (SD 42.8)min) compared with L-S (162.4 (SD 62.6) min) and inulin (292.4 (SD 66.7) min; P = 0.007). GE half-time and lag phase (L-L: 61 (SD 9); L-S: 57 (SD 10); IN-S: 52 (SD 10) min; P = 0.005) were also affected, with L-L being the slowest. Thirdly, inulin reduced GE lag and latency phases (P < 0.05) compared with NO-S. Lactulose accelerates OCTT but delays GE compared with inulin. Inulin accelerates the onset of stomach emptying, but it has no effect on GE half-time. For these reasons, inulin is the preferred substrate for the H-2 breath test.