Navigating chemical space for biology and medicine
Navigating chemical space for biology and medicine
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DOI：
10.1038/nature03193
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发表时间：
2004-12-16
期刊：
影响因子：
64.8
通讯作者：
Hopkins, A
中科院分区：
文献类型：
--
作者：
Lipinski, C;Hopkins, A
尽管在过去的世纪里，人们一直在用有机合成来寻找药物，但我们仍然远远没有粗略地研究出大量可能被创造出来的小分子。事实上，彻底检查所有的“化学空间”实际上是不可能的。鉴于此，识别调节生物靶点的小分子的最佳策略是什么？根据主要目标是了解生物系统还是开发潜在的药物，这些策略会有什么不同？
Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all 'chemical space' is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?