Glucose transporter-1 expression in squamous cell carcinoma of the tongue.
Glucose transporter-1 expression in squamous cell carcinoma of the tongue.
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DOI：
10.4143/crt.2007.39.3.109
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发表时间：
2007-09-01
影响因子：
4.6
通讯作者：
Kim, Jun Suk
中科院分区：
文献类型：
--
作者：
Choi, Yoon Seok;Kim, Seok Jin;Kim, Jun Suk
目的：肿瘤细胞表达缺氧相关蛋白，如葡萄糖转运蛋白-1 （Glut-1）。这些缺氧诱导的变化可能使肿瘤细胞在持续缺氧微环境下存活，而在缺氧条件下存活的肿瘤细胞可能发展出更具侵袭性的表型，从而导致预后不良。材料与方法：应用免疫组化方法分析60例舌鳞癌患者的Glut-1表达，并评价其与预后的关系。结果：Glut-1呈弥漫性膜样表达，Glut-1阳性肿瘤细胞中位数为60%（范围：0.0 ~ 90.0%）。Glut-1的高表达（阳性肿瘤细胞的百分比>或=中位数，60%）与原发病灶的位置、淋巴结转移状态和疾病分期有关(p
PURPOSE: Tumor cells are known to express hypoxia-related proteins such as glucose transporter-1 (Glut-1). These hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments, and the surviving tumor cell under hypoxia may develop a more aggressive phenotype and so result in a poor prognosis.MATERIALS AND METHODS: The Glut-1 expression was analyzed by immunohistochemistry, and its association with the prognosis was assessed in 60 patients with squamous cell carcinoma of the tongue.RESULTS: The Glut-1 expression was diffuse with a membranous pattern, and the median percentage of Glut-1 positive tumor cells was 60% (range: 0.0 approximately 90.0%). A high Glut-1 expression (the percentage of positive tumor cells >or= the median value, 60%) was associated with the location of primary lesion, lymph node metastasis status and disease stage (p