Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
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DOI：
10.1176/appi.ajp.164.4.674
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发表时间：
2007-04-01
影响因子：
17.7
通讯作者：
Faraone, Stephen V.
中科院分区：
文献类型：
--
作者：
Asherson, Philip;Brookes, Keeley;Faraone, Stephen V.
目的：本研究的主要目的是确认多巴胺转运蛋白基因的特定单倍型与注意缺陷多动障碍（ADHD）之间的关联，这可能是已发表研究中所见异质性的一个来源。作者之前报道过多动症与包含两个变量的特定等位基因的染色体亚组相关-多巴胺转运蛋白基因3'非翻译区和内含子8内的数目串联重复多态性。他们现在报告在ADHD合并型先证者的样本中的这种关联。结果：最初的观察结果得到证实，总体优势比为1.4在整个sample.Conclusions：这些数据挑战荟萃分析的结果表明，多巴胺转运蛋白的变异不会对ADHD的风险产生影响，他们表明，需要进一步调查基因的功能变异。
Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies.Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands.Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples.Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.