Two-component signal transduction systems and regulation of virulence factors in Xanthomonas: a perspective
Two-component signal transduction systems and regulation of virulence factors in Xanthomonas: a perspective
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DOI：
10.1007/s11515-010-0750-x
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发表时间：
2010-12
期刊：
影响因子：
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通讯作者：
Fang-Fang Wang-Fang;Li Wang;W. Qian
中科院分区：
文献类型：
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作者：
Fang-Fang Wang-Fang;Li Wang;W. Qian
由组氨酸激酶和反应调节因子组成的双组分信号转导系统（TCSTS）在革兰氏阴性植物病原细菌黄单胞菌（Xanthomonasspp.）毒力基因表达调控中起着重要作用。迄今为止，已鉴定出12个TCSTS基因，约占每个基因组中已通过实验鉴定为与发病机制相关的TCSTS基因的10%。这些TCSTS通过不同的分子机制调节许多毒力因子的表达，例如与DNA相互作用、蛋白质结合和参与第二信使代谢，这产生了高水平的调节多样性。在这里，我们总结了目前在这一领域的知识，并讨论了新出现的主题和剩余的问题，是重要的破译黄单胞菌TCSTS的信号网络。
Two-component signal transduction systems (TCSTSs), consisting of a histidine kinase and a response regulator, play a critical role in regulating virulence gene expression in Gram-negative phytopathogenic bacteriaXanthomonasspp.. To date, 12 TCSTS genes have been identified, accounting for approximately 10% of the TCSTS genes in each genome that have been experimentally identified to be related to pathogenesis. These TCSTSs modulate the expression of a number of virulence factors through diverse molecular mechanisms such as interacting with DNA, protein-binding and involvement in second messenger metabolism, which generates a high level of regulatory versatility. Here we summarize the current knowledge in this field and discuss the emerging themes and remaining questions that are important in deciphering the signaling network of TCSTSs inXanthomonas.