Effect of asbestos on lipid peroxidation in the red cells.
Effect of asbestos on lipid peroxidation in the red cells.
复制标题
石棉对红细胞脂质过氧化的影响。
DOI：
10.1136/oem.32.1.39
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
Z. Anca
中科院分区：
文献类型：
--
作者：
S. Gabor;Z. Anca
红细胞体外暴露于国际抗癌联盟 (UICC) 标准参考石棉样品中，导致硫代巴比妥酸物质增加。温石棉产生最多的脂质过氧化物，其次是直闪石、铁石棉和青石棉，按递减顺序排列。与不含灰尘的红细胞对照样品相比，所检测的所有类型的石棉都显示出显着差异。获得的结果为铁石棉和青石棉的细胞毒性潜力提供了支持，另一方面，表明不饱和脂肪酸的脂质过氧化可能涉及石棉粉尘的膜损伤作用机制。
In vitro exposure of red cells to vie International Union against Cancer (UICC) standard reference asbestos samples resulted in an increase of thiobarbituric acid substances. Chrysotiles developed the largest amounts of lipid peroxides, followed by anthophyllite, amosite, and crocidolite in decreasing order. Compared with the control samples erythrocytes free of dusts, all types of the asbestos examined disclosed significant differences. The results obtained provide support for the cytotoxic potential of amosite and crocidolite and, on the other hand, suggest that a lipid peroxidation of unsaturated fatty acids may be involved in the mechanisms(s) of membrane-damaging effects of asbestos dusts.