Gonadotroph adenomas of the human pituitary: sex-related fine-structural dichotomy. A histologic, immunocytochemical, and electron-microscopic study of 30 tumors.
Gonadotroph adenomas of the human pituitary: sex-related fine-structural dichotomy. A histologic, immunocytochemical, and electron-microscopic study of 30 tumors.
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人类垂体促性腺激素腺瘤：与性别相关的精细结构二分法。
DOI：
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发表时间：
1984
影响因子：
6
通讯作者：
K. Kovacs
中科院分区：
文献类型：
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作者：
É. Horváth;K. Kovacs
从14名男性和15名女性中切除的30个垂体肿瘤根据其免疫细胞化学和/或超微结构特征被诊断为促性腺腺瘤。8名男性血清促卵泡激素（FSH）升高，但黄体生成素（LH）未升高，而放射免疫测定的女性血清促性腺激素水平均不符合其年龄。15例男性肿瘤中有13例存在免疫反应性卵泡刺激素（有时也有LH），而13例女性腺瘤中只有6例。通过电镜观察，男性性腺激素腺瘤具有非特征性特征，通常与细胞质细胞器发育不良或中等发育的无细胞腺瘤相似。在女性患者中，所有肿瘤均分化良好，15例腺瘤中有14例诊断标记为高尔基体复体的高度独特的囊泡扩张（“蜂窝高尔基体”）。据作者所知，这是在细胞质细胞器，特别是高尔基体的超微结构外观明显不同的肿瘤类型中，性别连锁二分法的第一个例子。
Thirty pituitary tumors, removed from 14 men and 15 women, were diagnosed as gonadotroph adenomas on the basis of their immunocytochemical and/or ultrastructural features. Serum follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), was elevated in 8 men, whereas none of the women had gonadotropin levels, as measured by radioimmunoassay, inappropriately high for their age. Immunoreactive FSH (sometimes also LH) was present in 13 of 15 tumors in men but only 6 of 13 adenomas in women. By electron microscopy, gonadotroph adenomas in men had uncharacteristic features often similar to those of null-cell adenomas with poorly or moderately developed cytoplasmic organelles. In women, all tumors were well differentiated, with a highly distinctive vesicular dilatation of the Golgi complex ("honeycomb Golgi") as a diagnostic marker present in 14 of 15 adenomas. To the author's knowledge, this is the first example of sex-linked dichotomy within a tumor type expressed as the markedly different ultrastructural appearance of cytoplasmic organelles, especially the Golgi apparatus.