Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients.
Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients.
复制标题
预测 2 型糖尿病患者心脑血管事件的压力反射敏感性的性别差异。
DOI：
10.1253/circj.cj-10-1122
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
T. Saikawa
中科院分区：
文献类型：
--
作者：
K. Yufu;N. Takahashi;Norihiro Okada;O. Wakisaka;T. Shinohara;M. Nakagawa;M. Hara;H. Yoshimatsu;T. Saikawa
背景
BACKGROUND
Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM), and baroreflex sensitivity (BRS) reportedly can predict cardiovascular prognosis in type 2 DM patients. The hypothesis that cardiovascular events are associated with gender differences in BRS was tested in the present study.
METHODS AND RESULTS
From 1998, we have evaluated BRS by phenylephrine methods in 185 consecutive type 2 DM patients. The long-term prognostic value of BRS was compared between 91 female (5812 years) and 94 male patients (5811 years). There was no significant difference in age or severity and duration of DM between the 2 groups. When compared to male, the BRS value in female patients was significantly lower (9.266.0 vs. 5.975.0 ms/mmHg, P < 0.0001). During a mean of 62.7 months of follow-up, 16 female patients developed cardiovascular events (17.6%) including stroke, acute myocardial infarction, angina pectoris requiring percutaneous coronary intervention or coronary artery bypass grafting and congestive heart failure requiring admission, while only 4 male patients developed events (4.3%, P < 0.005). In females, the Kaplan-Meier curves revealed that those with depressed BRS (< 6 ms/mmHg) had a higher incidence of cardiovascular events than those with preserved BRS (P < 0.05), but this relationship was not observed in male patients.
CONCLUSIONS
Although the reason why females had a more depressed BRS remains unclear, our findings demonstrated that a depressed BRS value can accurately predict cardiovascular events, especially in female patients with type 2 DM.
影响因子：
24
作者：
Shaw, Leslee J.;Bugiardini, Raffaelle;Merz, C. Noel Bairey
通讯作者：
Merz, C. Noel Bairey
影响因子：
--
作者：
Kanaya, AM;Grady, D;Barrett-Connor, E
通讯作者：
Barrett-Connor, E