Current Options for Determining Fracture Union.
Current Options for Determining Fracture Union.
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DOI：
10.1155/2014/708574
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发表时间：
2014
影响因子：
--
通讯作者：
Morshed S
中科院分区：
文献类型：
--
作者：
Morshed S
确定骨折是否愈合是骨科最重要和最基本的临床决定之一。然而，目前还没有标准化的方法来评估骨折愈合，这反过来又造成了骨科医生在临床和研究环境中的重大分歧。大量的研究一直致力于寻找新的和可靠的方法来确定愈合与一些有希望的结果。影像学技术的最新进展和新的放射学评分的引入有助于减少医生在这一主题上的分歧。从骨愈合的生物力学研究中获得的知识帮助我们改进了我们的工具，并创造了更有效和实用的研究仪器。此外，对骨愈合过程中所涉及的分子途径的更深入理解已经导致血清学标记物作为骨折愈合评估的可能候选物的出现。除了我们目前以医生为中心的方法外，以患者为中心的方法评估生活质量和功能在骨折愈合评估中越来越受欢迎。尽管取得了这些进展，但在临床环境中，对愈合的评估仍然是一个不完善的实践。因此，临床医生需要利用多种方式，直接和间接测量或与骨愈合相关的咨询患者时。
Determining whether a bone fracture is healed is one of the most important and fundamental clinical determinations made in orthopaedics. However, there are currently no standardized methods of assessing fracture union, which in turn has created significant disagreement among orthopaedic surgeons in both clinical and research settings. An extensive amount of research has been dedicated to finding novel and reliable ways of determining healing with some promising results. Recent advancements in imaging techniques and introduction of new radiographic scores have helped decrease the amount of disagreement on this topic among physicians. The knowledge gained from biomechanical studies of bone healing has helped us refine our tools and create more efficient and practical research instruments. Additionally, a deeper understanding of the molecular pathways involved in the bone healing process has led to emergence of serologic markers as possible candidates in assessment of fracture union. In addition to our current physician centered methods, patient-centered approaches assessing quality of life and function are gaining popularity in assessment of fracture union. Despite these advances, assessment of union remains an imperfect practice in the clinical setting. Therefore, clinicians need to draw on multiple modalities that directly and indirectly measure or correlate with bone healing when counseling patients.