ASSOCIATION OF BACTEROIDES-FRAGILIS WITH CHILDHOOD DIARRHEA
ASSOCIATION OF BACTEROIDES-FRAGILIS WITH CHILDHOOD DIARRHEA
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DOI：
10.3109/00365549509019011
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发表时间：
1995-01-01
影响因子：
--
通讯作者：
SEARS, CL
中科院分区：
文献类型：
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作者：
SANJOAQUIN, VH;GRIFFIS, JC;SEARS, CL
最近发现易碎杆菌（ETBF）产肠毒素菌株与阿帕奇和孟加拉国儿童的腹泻有关。本研究旨在确定ETBF在城市儿童腹泻中的作用。对991例腹泻患儿和581例无症状年龄匹配对照的粪便标本进行脆弱芽孢杆菌（BF）培养。用人结肠上皮细胞系检测分离株肠毒素的产生。318例（32.1%）患者和123例（21.2%）对照组分离出BP （p < 0.001）。在占患者和对照组约50%的< 1岁儿童中，BF分离率具有可比性（26.5% vs 25.7%, p = 0.812），而大于或等于1岁儿童的分离率具有显著性差异（37.6% vs 16.5%, p = < 0.001）。总体而言，4.4%的患者和3.1%的对照组被确诊为ETBF （p = 0.2）。然而，在1-5岁儿童（5.4% vs 1.8%, p = 0.033）和1-10岁儿童（4.8% vs 1.5%, p = 0.021）中，ETBF与腹泻疾病显著相关。ETBF全年分离，分别占从患者和对照组分离的BF的14.4%和15%，这表明部分本地BF天生就是肠毒素的产生者。在本研究中，BP和ETBF与1-10岁儿童腹泻疾病相关。
Enterotoxigenic strains of Bacteriodes fragilis (ETBF) have recently been found to be associated with diarrheal illness in Apache and Bangladeshi children. This study was conducted to define the role of ETBF in diarrhea of children in an urban setting. Fecal specimens from 991 children with diarrhea and 581 asymptomatic age-matched controls were cultured for B. fragilis (BF). The isolates were tested for enterotoxin production using a human colonic epithelial cell line. BP was isolated from 318 (32.1%) of the patients and 123 (21.2%) of the controls (p < 0.001). In children < 1 year old which comprised about 50% of both patients and controls, the BF isolation rates were comparable (26.5% vs 25.7%; p = 0.812), contrasting with the significant difference in isolation rates for children greater than or equal to 1 year (37.6% vs 16.5%; p = < 0.001). Overall, ETBF were identified in 4.4% of patients and 3.1% of controls (p = 0.2). However, ETBF were significantly associated with diarrheal disease in children 1-5 years (5.4% vs 1.8%; p = 0.033) and 1-10 years (4.8% vs 1.5%; p = 0.021) in age. ETBF were isolated the year round and comprised 14.4% and 15% of the BF isolated from the patients and controls, respectively, suggesting that part of the indigenous BF are inherently enterotoxin producers. In this study, BP and ETBF were associated with diarrheal illness in children 1-10 years old.