Synthesis of betulinic acid derivatives with activity against human melanoma
Synthesis of betulinic acid derivatives with activity against human melanoma
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DOI：
10.1016/s0960-894x(98)00295-9
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发表时间：
1998-07-07
影响因子：
2.7
通讯作者：
Pisha, E
中科院分区：
文献类型：
--
作者：
Kim, DSHL;Pezzuto, JM;Pisha, E
桦木酸在 C-3、C-20 和 C-28 位点进行了修饰，并针对培养的人黑色素瘤 (MEL-2) 和人口腔表皮样癌 (KB) 细胞系评估了衍生物的毒性。这项初步研究表明，对桦木酸母体结构进行简单修饰可以产生潜在的重要衍生物，这些衍生物可以开发为抗肿瘤药物。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigation demonstrates that simple modifications of the parent structure of betulinic acid can produce potentially important derivatives, which may be developed as antitumor drugs. (C) 1998 Elsevier Science Ltd. All rights reserved.