Effect of adsorption kinetics on dissociation of DNA-nucleobases on gold nanoparticles under pulsed laser illumination.
Effect of adsorption kinetics on dissociation of DNA-nucleobases on gold nanoparticles under pulsed laser illumination.
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脉冲激光照射下金纳米粒子吸附动力学对 DNA 核碱基解离的影响
DOI：
10.1039/c6cp08433h
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
I. Bald
中科院分区：
文献类型：
--
作者：
R. Schürmann;I. Bald
光热疗法是一种通过激光照射掺入细胞中的金纳米颗粒 (GNP) 来提高温度来破坏癌细胞的新方法。在这里，我们通过纳秒激光脉冲照射金纳米粒子来研究 DNA 核碱基的分解。吸附和分解过程的动力学由基于 Langmuir 假设的理论模型描述，并与实验确定的反应速率相关，揭示了核碱基特异性吸附的强烈影响。除了四种核碱基之外，还研究了它们的溴化类似物，它们是癌症治疗中潜在的放射增敏剂，并显示出分解速率的显着改变。腺嘌呤、8-溴腺嘌呤、8-溴鸟嘌呤和 5-溴胞嘧啶的分解速率最快。这些结果与考虑不均匀表面影响的 GNP 聚集动力学确定的相对吸附率非常一致。对于腺嘌呤及其溴化类似物，通过表面增强拉曼散射 (SERS) 进一步分析分解产物，表明分子强烈碎裂成最小的亚基。
Photothermal therapy is a novel approach to destroy cancer cells by an increase of temperature due to laser illumination of gold nanoparticles (GNPs) that are incorporated into the cells. Here, we study the decomposition of DNA nucleobases via irradiation of gold nanoparticles with ns-laser pulses. The kinetics of the adsorption and decomposition process is described by a theoretical model based on the Langmuir assumptions and correlated with experimentally determined reaction rates revealing a strong influence of the nucleobase specific adsorption. Beside the four nucleobases, their brominated analogs, which are potential radiosensitizers in cancer therapy, are also investigated and show a significant modification of the decomposition rates. The fastest decomposition rates are observed for adenine, 8-bromoadenine, 8-bromoguanine and 5-bromocytosine. These results are in good agreement with the relative adsorption rates that are determined from the aggregation kinetics of the GNPs taking the effect of an inhomogeneous surface into account. For adenine and its brominated analog, the decomposition products are further analyzed by surface enhanced Raman scattering (SERS) indicating a strong fragmentation of the molecules into their smallest subunits.
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影响因子：
14.5
作者：
Shay JW;Wright WE
通讯作者：
Wright WE
单激光脉冲诱导金纳米颗粒聚集
DOI：
--
发表时间：
2007
期刊：
Physical Chemistry Chemical Physics 9
影响因子：
--
作者：
Muto;Yamada;Miyajima;Mafune
通讯作者：
Mafune
影响因子：
2.8
作者：
Wieczor, Milosz;Wityk, Pawel;Rak, Janusz
通讯作者：
Rak, Janusz
影响因子：
3.9
作者：
Zhang, Xu;Servos, Mark R.;Liu, Juewen
通讯作者：
Liu, Juewen
影响因子：
16.6
作者：
Rackwitz, Jenny;Kopyra, Janina;Bald, Ilko
通讯作者：
Bald, Ilko