Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast
Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast
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DOI：
10.1117/1.jbo.17.5.056007
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发表时间：
2012-05-01
影响因子：
3.5
通讯作者：
Gulsen, Gultekin
中科院分区：
文献类型：
--
作者：
Lin, Yuting;Kwong, Tiffany C.;Gulsen, Gultekin
在高散射介质中对荧光物体进行高空间分辨率成像是一项具有挑战性的工作。最近报道的温度敏感的吲哚菁绿负载普朗尼克纳米胶囊可以潜在地缓解这个问题。在这里，我们展示了一个频域温度调制荧光断层扫描系统，可以获得高强度聚焦超声分辨率的图像与使用这些纳米胶囊。该系统的实验验证与幻影的研究，其中3毫米的荧光物体嵌入2厘米深的混浊介质中成功地恢复的基础上的强度和寿命的对比度。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.5.056007]
It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography system that could acquire images at high intensity-focused ultrasound resolution with use of these nanocapsules. The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.5.056007]