Active immunization of hamsters against experimental infection with Borrelia burgdorferi
Active immunization of hamsters against experimental infection with Borrelia burgdorferi
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仓鼠对伯氏疏螺旋体实验性感染的主动免疫
DOI：
10.1128/iai.54.3.897-898.1986
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发表时间：
1986
影响因子：
3.1
通讯作者：
M. Russell
中科院分区：
文献类型：
--
作者：
R. C. Johnson;C. Kodner;M. Russell
评价了单剂量灭活伯氏疏螺旋体HSF（人脊髓液分离株）全细胞疫苗的免疫原性。对叙利亚仓鼠进行皮下接种，并通过腹膜内注射1，000 50%感染剂量的B进行攻击。接种后30或90天的伯氏HSF。攻毒后14天处死动物，通过培养程序检查肾脏和脾脏的螺旋体。接种后30天，接种50和100微克（干重）疫苗的仓鼠获得了86%至100%的感染保护。25微克疫苗的保护率下降到60%，10微克疫苗则没有保护率。接种后90天，100、50和25微克疫苗剂量的感染抵抗力分别下降至25%、40%和5%。
The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccination. Animals were sacrificed 14 days after challenge, and the kidneys and spleens were examined for spirochetes by cultural procedures. At 30 days postvaccination, 86 to 100% protection against infection was achieved in hamsters receiving 50 and 100 micrograms (dry weight) of vaccine. Protection was decreased to 60% with 25 micrograms of vaccine and was absent with 10 micrograms of vaccine. Resistance to infection decreased to 25, 40, and 5% for the 100-, 50-, and 25-micrograms vaccine doses, respectively, at 90 days postvaccination.
狗身上由伯氏疏螺旋体引起的关节炎。
DOI：
--
发表时间：
1985
期刊：
Journal of the American Veterinary Medical Association
影响因子：
--
作者：
Kornblatt,AN;Urband,PH;Steere,AC
通讯作者：
Steere,AC
影响因子：
158.5
作者：
STEERE, AC;GRODZICKI, RL;MALAWISTA, SE
通讯作者：
MALAWISTA, SE