Experimental cyclosporin A nephrotoxicity.
Experimental cyclosporin A nephrotoxicity.
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实验性环孢菌素 A 肾毒性。
DOI：
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发表时间：
1982
影响因子：
--
通讯作者：
J. G. Simpson
中科院分区：
文献类型：
--
作者：
P. Whiting;A. Thomson;J. T. Blair;J. G. Simpson
在Sprague-Dawley大鼠组中研究了环孢素A（Cy A）的肾毒性，给予不同剂量方案，持续21天。肾小球滤过功能受损明显表现为血清尿素和肌酐水平升高以及尿素清除率降低。尿N-乙酰基-β-D-氨基葡萄糖苷酶活性也出现剂量相关增加。这些生化变化伴有近端小管直段损伤的结构证据;这包括不同程度的细胞质空泡化，这是由于光滑和粗糙内质网扩张所致，在最高试验剂量下，偶尔出现单个细胞坏死和脱皮。超微结构检查显示影响近端小管全长的其他剂量相关异常，包括溶酶体生成增加以及细胞质小体和髓样小体形成。
The nephrotoxic property of cyclosporin A (Cy A) was investigated in groups of Sprague-Dawley rats given various dose regimes over a 21-day period. Impairment of glomerular filtration was clearly evidenced by elevated serum urea and creatinine levels and by reduced urea clearance rates. There were also dose-related increases in urinary N-acetyl-beta-D-glucosaminidase activity. These biochemical changes were accompanied by structural evidence of damage to the straight segment of the proximal tubule; this consisted of varying degrees of cytoplasmic vacuolation, due to dilatation of both smooth and rough endoplasmic reticulum, and, at the highest dose tested, occasional individual cell necrosis and desquamation. Ultrastructural examination revealed additional dose-related abnormalities affecting the entire length of the proximal tubule, including increased lysosome production and the formation of cytosegresomes and myeloid bodies.
肝移植，1980 年，特别提到环孢菌素-A。
影响因子：
0.9
作者：
Starzl,TE;Iwatsuki,S;Klintmalm,G;Schröter,GP;Weil3rd,R;Koep,LJ;Porter,KA
通讯作者：
Porter,KA