Maternal nutrition during pregnancy and health of the offspring
Maternal nutrition during pregnancy and health of the offspring
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DOI：
10.1042/bst0340779
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发表时间：
2006-11-01
影响因子：
3.9
通讯作者：
Ozanne, S. E.
中科院分区：
文献类型：
--
作者：
Martin-Gronert, M. S.;Ozanne, S. E.
母亲为婴儿提供营养和氧气的能力是胎儿健康和存活的关键因素。如果不能提供足够的营养来满足胎儿的需求，可能会导致胎儿营养不良。胎儿会对营养不足做出反应和适应，但这样做会永久地改变身体的结构和功能。母亲营养过剩也对后代的健康产生长期和有害的影响。越来越多的证据表明，母体营养可以诱导胎儿基因组的表观遗传修饰。仅在相对最近才出现来自流行病学和动物研究的证据，表明胎儿对子宫内环境的反应可能是许多成年慢性疾病包括2型（非胰岛素依赖性）糖尿病的流行的基础。现在至关重要的是，要了解胎儿宫内环境的改变及其对个体健康的长期影响之间关系的分子机制。
The ability of mother to provide nutrients and oxygen for her baby is a critical factor for fetal health and its survival. Failure in supplying the adequate amount of nutrients to meet fetal demand can lead to fetal malnutrition. The fetus responds and adapts to undernutrition but by doing so it permanently alters the structure and function of the body. Maternal overnutrition also has long-lasting and detrimental effects on the health of the offspring. There is growing evidence that maternal nutrition can induce epigenetic modifications of the fetal genome. only relatively recently has evidence from epidemiological and animal studies emerged suggesting that fetal responses to the intrauterine environment may underlie the prevalence of many chronic diseases of adulthood including Type 2 (non-insulin-dependent) diabetes. It is now of crucial importance to gain the understanding of the molecular mechanisms underlying the relationship between fetal alterations to the intra-uterine environment and their long-term effects on the health of an individual.