Association of unexplained infertility with gonadotropin and ovarian antibodies.
Association of unexplained infertility with gonadotropin and ovarian antibodies.
复制标题
不明原因不孕与促性腺激素和卵巢抗体的关联。
DOI：
10.1111/j.1600-0897.2006.00428.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Luborsky,JudithL
中科院分区：
文献类型：
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作者：
Shatavi,SeerinV;Llanes,Brainard;Luborsky,JudithL
问题确定与不明原因不孕症相关的促性腺激素自身抗体（GAB）的患病率和特征，并评估卵巢自身抗体（OvAB）与GAB之间的关系。研究方法采用免疫分析法检测不明原因不孕症患者（n= 53）和血库对照组（n= 40）血清中的卵巢抗体和GAB。 不明原因不孕症患者要么没有事先促性腺激素治疗（n= 15）或两个或两个以上的促性腺激素周期，以诱导排卵（n= 38）。结果GABs检测到67%的妇女治疗，27%的妇女没有治疗和8%的妇女在人口中。 GABs识别促卵泡激素（FSH）和促黄体生成激素（LH）及其α和β亚基，并在较小程度上识别促甲状腺激素（TSH）和催乳素。促性腺激素治疗组和未治疗组的OVAB患病率无显著性差异，而GABs在促性腺激素治疗组的患病率显著高于未治疗组（P≤ 0.01）。结论促性腺激素抗体与OVAB相关，可能是不明原因不孕症患者卵巢自身免疫的一个独立标志物，且存在于未接受促性腺激素治疗的患者中。 然而，由于更高频率的GAB与促性腺激素治疗相关，卵巢自身免疫患者除了内分泌反应外，可能倾向于对促性腺激素产生免疫反应。
ProblemTo determine the prevalence and characteristics of gonadotropin autoantibodies (GAB) associated with unexplained infertility, and to assess the relationship between ovarian autoantibodies (OVAB) and GAB.Method of studyOvarian antibodies and GABs in sera of patients with unexplained infertility (n= 53) and a comparison (population) group from a blood bank (n= 40) were detected by immunoassay. Patients with unexplained infertility had either no prior gonadotropin treatment (n= 15) or two or more gonadotropin cycles to induce ovulation (n= 38).ResultsThe GABs were detected in 67% of women with treatment, 27% of women without treatment and 8% of women in the population. The GABs recognized follicle stimulating hormone (FSH) and luteinizing hormone (LH) and their alpha and beta subunits and to a lesser extent thyroid stimulating hormone (TSH) and prolactin. There was no significant difference in OVAB prevalence between gonadotropin treated or untreated women while GABs were significantly more frequent in gonadotropin treated women (P≤ 0.01).ConclusionGonadotropin antibodies may represent a separate marker of ovarian autoimmunity in unexplained infertility as they are correlated with OVAB and are present in patients not treated with gonadotropin. However, as a higher frequency of GAB is associated with gonadotropin treatment, patients with ovarian autoimmunity may tend to have an immune response to gonadotropins in addition to an endocrine response.