Increased anti-Mullerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome
Increased anti-Mullerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome
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DOI：
10.1210/jc.2005-2693
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发表时间：
2006-08-01
影响因子：
5.8
通讯作者：
Cassorla, Fernando
中科院分区：
文献类型：
--
作者：
Sir-Petermann, Teresa;Codner, Ethel;Cassorla, Fernando
背景：抗苗勒管激素（AMH）是由颗粒细胞产生的，反映卵泡发育。患有多囊卵巢综合征（PCOS）的成年女性AMH水平升高，与过多的卵泡生长有关。然而，目前尚不清楚这些异常是否存在于临床发病前的PCOS.Objective：我们的目的是调查是否青春期前的女儿PCOS的妇女有增加AMH levels.Design：14名女婴（2-3个月大）和25青春期前的女孩（4-7岁）出生的PCOS母亲进行了研究。作为对照组，我们研究了21名女婴和24名青春期前的女孩所生的母亲月经规律，没有高雄激素血症。PCOS母亲组和对照组出生体重正常，均为自发单胎妊娠。结果：PCOS组婴儿早期血清AMH浓度显著高于对照组，PCOS组婴儿早期血清AMH浓度显著高于对照组（20.4 +/- 15.6 vs. 9.16 +/- 8.6 pmol/L; P = 0.024）和儿童期（14.8 +/- 7.7 vs. 9.61 +/- 4.4 pmol/L; P = 0.007）。促性腺激素和血清性类固醇浓度在两个研究期间，在两组相似，除了FSH，这是在儿童时期出生的PCOS mothers.Conclusions的女孩较低：我们得出结论，血清AMH浓度增加青春期前的PCOS妇女的女儿，这表明这些女孩出现在婴儿期和儿童期的卵泡发育改变的证据。
Context: Anti-Mullerian hormone (AMH) is produced by the granulosa cells and reflects follicular development. Adult women with polycystic ovary syndrome ( PCOS) have increased levels of AMH associated with an excessive number of growing follicles. However, it is not known whether these abnormalities are present before the clinical onset of PCOS.Objective: Our objective was to investigate whether prepubertal daughters of women with PCOS have increased AMH levels.Design: Fourteen female infants (2-3 months old) and 25 prepubertal girls (4-7 yr old) born to PCOS mothers were studied. As a control group, we studied 21 female infants and 24 prepubertal girls born to mothers with regular menses and without hyperandrogenism. The group with PCOS mothers and the control group had normal birth weight and were born from spontaneous singleton pregnancies. Circulating concentrations of gonadotropins, testosterone, androstenedione, estradiol, 17-OH-progesterone, SHBG, inhibin B, and AMH were determined by specific assays.Results: Serum concentrations of AMH were significantly higher in the PCOS group compared with the control group during early infancy (20.4 +/- 15.6 vs. 9.16 +/- 8.6 pmol/liter; P = 0.024) and during childhood (14.8 +/- 7.7 vs. 9.61 +/- 4.4 pmol/liter; P = 0.007). Gonadotropin and serum sex steroid concentrations were similar in both groups during the two study periods, except for FSH, which was lower during childhood in girls born to PCOS mothers.Conclusions: We conclude that serum AMH concentrations are increased in prepubertal daughters of PCOS women, suggesting that these girls appear to show evidence of an altered follicular development during infancy and childhood.