Re-irradiation of head and neck cancer-impact of total dose on outcome.
Re-irradiation of head and neck cancer-impact of total dose on outcome.
复制标题
头颈癌的再照射——总剂量对结果的影响。
作者：
S. Janssen;M. Baumgartner;M. Bremer;A. Warszawski;M. Stieve;A. Eckardt;J. Karstens;A. Meyer
目标
评估再次照射的结果，并确定有利的前处理特性。
患者和方法
75例局部复发的头颈癌患者接受了再次放射治疗，无论是术后再照射还是明确治疗，同时加用或不加化疗。第一次和第二次照射之间的平均时间为19个月。再次照射的平均总剂量为46Gy.中位随访期8.7个月。
结果
两年后总生存率、局部无瘤生存率和无转移生存率分别为23%、24%和77%。再照射总剂量越高，总体存活率在统计学上越好(p=0.018)。
结论
对于局部复发的头颈癌患者，再次放疗是一种可行的治疗方案。再次照射时的总剂量可提高总体存活率。因此，只有在给予足够的≥46GY总剂量的情况下，才能进行具有治疗意图的再次照射。
AIM
To evaluate the outcome of re-irradiation and to define favourable pre-treatment characteristics.
PATIENTS AND METHODS
seventy-five patients with locally recurrent head and neck cancer were treated with re-irradiation, either postoperatively or as definitive treatment, with and without chemotherapy. Mean time period between first and second series of irradiation was 19 months. Mean overall dose of re-irradiation was 46 Gy. Median follow-up was 8.7 months.
RESULTS
Overall survival, loco-regional disease-free survival and metastasis-free survival after two years were 23%, 24% and 77%, respectively. Higher overall doses of re-irradiation gave a statistically significant better outcome with regard to overall survival (p=0.018).
CONCLUSION
For patients with locally recurrent head and neck cancer, re-irradiation is a feasible therapeutic option. The total dose at re-irradiation improves overall survival. Therefore, re-irradiation with curative intent should only be applied if a sufficient total dose of ≥46 Gy can be given.
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M
影响因子：
50.5
作者：
Brockstein, B;Haraf, DJ;Vokes, EE
通讯作者：
Vokes, EE
以治愈为目的对复发性头颈癌进行再照射。
DOI：
10.1053/j.seminoncol.2004.09.003
发表时间：
2004
期刊：
Seminars in oncology.
影响因子：
--
作者：
Chmura,StevenJ;Milano,MichaelT;Haraf,DanielJ
通讯作者：
Haraf,DanielJ