Macrophage colony-stimulating factor (M-CSF), as well as granulocyte colony-stimulating factor (G-CSF), accelerates neovascularization
Macrophage colony-stimulating factor (M-CSF), as well as granulocyte colony-stimulating factor (G-CSF), accelerates neovascularization
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DOI：
10.1634/stemcells.2004-0190
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发表时间：
2005-03-01
期刊：
影响因子：
5.2
通讯作者：
Ikehara, S
中科院分区：
文献类型：
--
作者：
Minamino, K;Adachi, Y;Ikehara, S
有报道称，骨髓细胞(BMC)可分化为血管内皮细胞，粒细胞集落刺激因子(G-CSF)可动员骨髓细胞中的祖细胞进入外周血，而巨噬细胞集落刺激因子(M-CSF)可促进单核细胞的生成。我们利用后肢缺血模型研究了M-CSF是否能促进骨髓基质细胞分化为血管内皮细胞。给后肢缺血小鼠注射G-CSF和/或M-CSF，连续3天。M-CSF和G-CSF均通过血管内皮细胞生长因子(VEGF)促进骨髓基质细胞向血管内皮细胞分化，使缺血肢体血流量早日恢复。
It has been reported that bone marrow cells (BMCs) differentiate into endothelial cells of blood vessels, and that granulocyte colony-stimulating factor (G-CSF) mobilizes progenitors in the BMCs to the peripheral blood, while macrophage colony-stimulating factor (M-CSF) augments the production of monocytes. We examined whether M-CSF augments the differentiation of BMCs into endothelial cells of blood vessels using a hindlimb-ischemic model. Either G-CSF or M-CSF, or both, was administered to the hindlimb-ischemic mice for 3 days. Both M-CSF and G-CSF augmented the differentiation of BMCs into endothelial cells of blood vessels through vascular endothelial cell growth factor (VEGF), resulting in early recovery of blood flow in the ischemic limbs.