Voltage-Gated Calcium Channels
Voltage-Gated Calcium Channels
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DOI：
10.1101/cshperspect.a003947
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发表时间：
2011-08-01
影响因子：
7.2
通讯作者：
Catterall, William A.
中科院分区：
文献类型：
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作者：
Catterall, William A.
电压门控钙（Ca2+）通道是将膜电位变化转化为细胞内Ca2+瞬变的关键转换器，所述细胞内Ca2+瞬变引发许多生理事件。在哺乳动物中，电压门控性Ca 2+通道家族有10个成员，它们在细胞信号转导中发挥不同的作用。Ca（V）1亚家族启动收缩、分泌、基因表达的调节、神经元中突触输入的整合以及特化感觉细胞中带状突触处的突触传递。Ca（V）2亚家族主要负责启动快速突触的突触传递。Ca（V）3亚家族对于心肌细胞和丘脑神经元等节律性放电细胞中动作电位的重复放电非常重要。本文介绍了这些Ca2+通道蛋白的分子关系和生理功能，并提供了它们的分子，遗传，生理和药理学特性的信息。
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential changes into intracellular Ca2+ transients that initiate many physiological events. There are ten members of the voltage-gated Ca2+ channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca2+ channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.