Influence of scheduled restricted feeding on reentrainment of motor activity rhythm after a 6-h light-dark advance in rats
Influence of scheduled restricted feeding on reentrainment of motor activity rhythm after a 6-h light-dark advance in rats
复制标题
DOI：
10.3922/j.psns.2011.3.004
复制
发表时间：
2011-12-01
影响因子：
--
通讯作者：
Araujo, John F
中科院分区：
文献类型：
--
作者：
Carneiro, Breno T.S.;Araujo, John F
昼夜节律被引入到周期性的环境线索中，如明暗周期和食物供应。下丘脑的视交叉上核是哺乳动物中主要的昼夜节律振荡器，主要受明暗周期的影响，尽管在某些实验情况下食物的可获得性会影响其振荡。在这里，我们测试了预定的限制喂养是否能够影响运动活动节律的再夹带（即，由视交叉上核控制的行为节律）到光-暗周期的6小时相位提前。将大鼠置于标准的12 h：12 h光暗周期中饲养18 d，然后提前熄灯。与随意进食的对照组大鼠相比，在明-暗转换的第一天开始接受计划限制性喂养的大鼠表现出更快的运动活动节律的再夹带。结果表明，预定喂养有效地加速了行为昼夜节律的再夹带，并建议该程序可能会影响视交叉上核的活动在再夹带到明暗变化的阶段。
Circadian rhythms are entrained to cyclic environmental cues such as the light-dark cycle and food availability. The suprachiasmatic nucleus of the hypothalamus is the main circadian oscillator in mammals and is entrained primarily by the light-dark cycle, although in some experimental situations food availability can affect its oscillation. Here we tested whether scheduled restricted feeding is capable of influencing the reentrainment of the motor activity rhythm (i.e., a behavioral rhythm controlled by the suprachiasmatic nucleus) to a 6-h phase advance of the light-dark cycle. Rats were housed in a standard 12 h:12 h light-dark cycle for 18 days, and then the time of lights-off was advanced. Rats subjected to scheduled restricted feeding starting on the first day of the light-dark shift showed faster reentrainment of the motor activity rhythm compared with control rats maintained with ad libitum food. The results showed that scheduled feeding effectively accelerates reentrainment of a behavioral circadian rhythm and suggest that the procedure may affect activity in the suprachiasmatic nucleus during the stage of reentrainment to light-dark shifts.