Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses
Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses
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DOI：
10.1111/j.1365-2133.1986.tb02773.x
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发表时间：
1986-01
影响因子：
10.3
通讯作者：
H. Takematsu;K. Ohkohchi;H. Tagami
中科院分区：
文献类型：
--
作者：
H. Takematsu;K. Ohkohchi;H. Tagami
补体成分C3a，C4a，和C5a，从银屑病和其他皮肤病的特点是无菌角膜下脓疱的角膜鳞屑提取物，用放射免疫测定法测定。在银屑病和相关脓疱性皮肤病中检测到的量大于非炎性角质层提取物。它的结论是，补体激活通过经典途径，并释放中性粒细胞趋化片段C5a。
Complement components C3a, C4a, and C5a, were assayed in corneal scale extracts from psoriasis and other dermatoses characterized by sterile subcorneal pustules, using radioimmunoassay. Larger amounts were detected in psoriasis and related pustular dermatoses than in extracts of non‐inflammatory stratum corneum. It is concluded that complement is activated via the classical pathway and releases the neutrophil chemotactic fragment C5a.