Flavonoids intake and risk of prostate cancer: a meta-analysis of observational studies
Flavonoids intake and risk of prostate cancer: a meta-analysis of observational studies
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DOI：
10.1111/and.12556
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发表时间：
2016-12-01
期刊：
影响因子：
2.4
通讯作者：
Wang, H.
中科院分区：
文献类型：
--
作者：
Guo, K.;Liang, Z.;Wang, H.
该研究的目的是评估总黄酮/类黄酮亚类摄入量与前列腺癌风险之间的关系。检索了几个数据库以选择符合预定义标准的合格研究。采用95%置信区间（ci）的风险比（rr）作为效应量。进行发表偏倚和敏感性分析。meta分析共纳入5项研究，包括4项前瞻性队列研究和1项病例对照研究。综合结果显示，摄入较高的总黄酮可显著增加前列腺癌的风险（RR = 1.12, 95% CI: 1.02-1.23, P = 0.013）。然而，敏感性分析显示，在剔除Wang等人的研究后，两者之间缺乏显著相关性（RR = 1.17, 95% CI: 0.94-1.46）。按类黄酮亚类分层的亚组分析发现，较高的花青素和黄烷-3-醇摄入量与前列腺癌风险增加显著相关（RR = 1.12, 95% CI: 1.03-1.21, P = 0.011; RR = 1.21, 95% CI: 1.10-1.32, P < 0.001）。敏感性分析也表明，在剔除Wang的研究后，花青素摄入量与前列腺癌风险之间未发现显著相关性（RR = 1.22, 95% CI: 0.97-1.54）。总之，摄入较多的类黄酮可能与患前列腺癌的风险无关。
The aim of the study was to assess the association between total flavonoids/flavonoid subclasses intake and prostate cancer risk. Several databases were searched to select eligible studies with predefined criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were used as the effect size. Publication bias and sensitivity analysis were performed. A total of five studies including four prospective cohort studies and one case-control study were included in the meta-analysis. The pooled result demonstrated a significantly increased risk of prostate cancer with higher intake of total flavonoids (RR = 1.12, 95% CI: 1.02-1.23, P = 0.013). However, sensitivity analysis indicated that there lacked a significant association after removing the study of Wang et al. (RR = 1.17, 95% CI: 0.94-1.46). Subgroup analysis stratified by flavonoids subclasses found that higher intake of anthocyanidins and flavan-3-ols were significantly associated with increased prostate cancer risk (RR = 1.12, 95% CI: 1.03-1.21, P = 0.011; RR = 1.21, 95% CI: 1.10-1.32, P < 0.001). Sensitivity analysis also indicated that after removing Wang's study, no significant association between anthocyanidins intake and prostate cancer risk was detected (RR = 1.22, 95% CI: 0.97-1.54). In conclusion, higher intake of flavonoids may not be associated with prostate cancer risk.