Prospective associations of early-onset Axis I disorders with developing eating disorders.
Prospective associations of early-onset Axis I disorders with developing eating disorders.
复制标题
早发性轴 I 疾病与饮食失调的前瞻性关联。
DOI：
10.1016/j.comppsych.2008.05.004
复制
发表时间：
2009
影响因子：
7.3
通讯作者：
Kaprio,Jaakko
中科院分区：
文献类型：
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作者：
Sihvola,Elina;Keski-Rahkonen,Anna;Dick,DanielleM;Hoek,HansW;Raevuori,Anu;Rose,RichardJ;Pulkkinen,Lea;Marttunen,Mauri;Kaprio,Jaakko
方法对1983 ~ 1987年出生的1318对青少年双生子进行了14岁时的半结构化精神病学调查，并进行了问卷调查。在17.5岁时，重度抑郁症显著预测了17.5岁时的焦虑障碍。（比值比，5.9; 95%置信区间，2.6-15.3）和广泛性焦虑症（GAD）（比值比，4.7; 95%置信区间，1.8-15.6），当排除基线ED时。早发性重度抑郁症合并广泛性焦虑症与单独的情绪障碍或焦虑症相比，增加了发展为ED的可能性。相似的风险和趋势是明显的双胞胎对不一致的基线预测和艾德outcome. CONCLUSIONSDressive障碍和广泛性焦虑症，表现在14岁的家庭内分析预测未来的ED。对不一致双胞胎的分析表明，早发性抑郁症和广泛性焦虑症与青春期ED有前瞻性相关，即使考虑到家庭因素。
OBJECTIVEThe purpose of this study is to analyze the developmental relationships of adolescent-onset Axis I mental disorders and eating disorders (EDs).METHODOne thousand three hundred eighteen adolescent twins born from 1983 to 1987 completed a professionally administered semistructured psychiatric interview at the age of 14 years and a questionnaire follow-up at the age of 17.5 years.RESULTSEating disorders at the age of 17.5 years were significantly predicted by major depressive disorder (odds ratio, 5.9; 95% confidence interval, 2.6-15.3) and generalized anxiety disorder (GAD) (odds ratio, 4.7; 95% confidence interval, 1.8-15.6) at the age of 14 years, when baseline EDs were excluded. Early-onset major depressive disorder in combination with GAD increased the likelihood of developing EDs compared with either mood or anxiety disorders alone. Similar risks and trends were evident in within-family analyses of twin pairs discordant for baseline predictors and ED outcome.CONCLUSIONSDepressive disorder and GAD that manifest at that age of 14 years predict future EDs. Analysis of discordant twins suggested that early-onset depressive disorder and GAD prospectively relate to EDs in adolescence, even after familial factors are taken into account.