Quipazine increases renin release by a peripheral hemodynamic mechanism.
Quipazine increases renin release by a peripheral hemodynamic mechanism.
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奎帕嗪通过外周血流动力学机制增加肾素释放。
DOI：
10.1097/00005344-199001000-00001
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发表时间：
1990
影响因子：
3
通讯作者：
Alper,RH
中科院分区：
文献类型：
--
作者：
Zink3rd,MH;Pergola,PE;Doane,JF;Sved,AF;Alper,RH
5-羟色胺（5-HT）激动剂的全身给药可引起血浆肾素活性（PRA）和动脉压（AP）的升高。为了验证这一假设，在清醒的雄性大鼠侧脑室（icv）或静脉（iv）给药5-HT激动剂奎帕嗪后，测定了血液动力学反应。iv喹帕嗪可增加AP和PRA，并减少雷纳血流量（RBF）; icv可增加AP至相似程度的喹帕嗪剂量不能增加PRA。普萘洛尔不能阻断静脉注射喹嗪引起的PRA升高，提示非神经机制。单独或联合应用哌唑嗪、依那普利或V1-加压素拮抗剂均不能消除iv喹嗪引起的AP增加和RBF降低。5-HT 2拮抗剂LY 53857进入中枢神经系统，阻断iv喹帕嗪的所有反应.而外周5-HT 2受体拮抗剂昔脒则阻断了对肾素和RBF的反应，但仅减弱了对喹帕嗪的升压反应。这些数据表明，喹帕嗪可以在中枢神经系统中增加AP，但当全身给药时，喹帕嗪也激活血管5-HT 2受体，以进一步增加AP并降低RBF。静脉注射奎帕嗪引起的PRA增加继发于肾血流动力学，与该药的CNS作用无关。
Systemically administered serotonin (5-HT) agonists have been suggested to act centrally to increase plasma renin activity (PRA) and arterial pressure (AP) To test this hypothesis, hemodynamic responses were determined in conscious male rats after intracerebroventricular (icv) or intravenous (iv) administration of the di rect 5-HT agonist quipazine. When administered iv quipazine increased AP and PRA, and decreased rena blood flow (RBF); doses of quipazine icv that increasec AP to a similar degree failed to increase PRA. The in crease in PRA elicited by iv quipazine was not blockec by propranolol, suggesting non-neural mechanisms. The increase in AP and decrease in RBF elicited by iv quipazine were not eliminated by prazosin, enalapril, or V 1-vasopressin antagonist administered alone or in combination. LY 53857, a 5-HT 2 antagonist that enters the central nervous system (CNS), blocked all responses to iv quipazine. In contrast, the peripheral 5-HT 2 antagonist xylamidine blocked the renin and RBF responses, but only attenuated the pressor response to quipazine. These data suggest that quipazine can act in the CNS to increase AP, but when administered systemically quipazine also activates vascular 5-HT 2 receptors to increase AP further and to decrease RBF. The increase in PRA caused by iv quipazine is secondary to renal hemodynamics and is unrelated to CNS actions of this drug.
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培养中的静止小鼠乳腺癌细胞的 DNA 损伤修复。
DOI：
10.1016/0167-4781(85)90043-0
发表时间：
1985
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Warters,RL;Lyons,BW;Ridinger,DN;Dethlefsen,LA
通讯作者：
Dethlefsen,LA
哺乳动物 DNA 合成对 DNA 超螺旋的依赖性。
DOI：
10.1016/0005-2787(81)90160-x
发表时间：
1981
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
M. Mattern;D. Scudiero
通讯作者：
D. Scudiero
DOI：
10.1073/pnas.81.5.1361
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
NELSON, EM;TEWEY, KM;LIU, LF
通讯作者：
LIU, LF
Crithidia fasciculata 动质体 DNA 网络和小环的分离和表征。
DOI：
10.1111/j.1550-7408.1974.tb03751.x
发表时间：
1974
期刊：
The Journal of protozoology
影响因子：
--
作者：
A. M. Simpson;L. Simpson
通讯作者：
L. Simpson
来自 HeLa 细胞核的同质 II 型 DNA 拓扑异构酶。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Miller,KG;Liu,LF;Englund,PT
通讯作者：
Englund,PT