Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches.
Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches.
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DOI：
10.1186/1532-429x-15-46
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发表时间：
2013-05-28
期刊：
影响因子：
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通讯作者：
Neubauer S
中科院分区：
文献类型：
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作者：
Petersen SE;Matthews PM;Bamberg F;Bluemke DA;Francis JM;Friedrich MG;Leeson P;Nagel E;Plein S;Rademakers FE;Young AA;Garratt S;Peakman T;Sellors J;Collins R;Neubauer S
英国生物银行是一项前瞻性队列研究，有50万名年龄在40至69岁之间的参与者。最近，一项增强成像研究获得了资助。心血管磁共振（CMR）将成为3-4个专门的英国生物银行成像中心的多器官、多模式成像访问的一部分，这些中心将获取和存储来自10万名参与者的成像数据（取决于成功的试点）。在每个UK Biobank的专用定制成像中心，建议15-20名参与者在5-6年的时间里，每周7天，每天接受2 - 3小时的访问。成像方式将包括3特斯拉的脑部MRI， 1.5特斯拉的CMR和腹部MRI，颈动脉超声和DEXA扫描，使用精心选择的方案。我们回顾了使用CMR进行如此大规模的简明表型分析的基本原理、挑战和提出的方法。在这里，我们讨论了这种影像学研究的好处，并回顾了现有的和计划中的前瞻性队列研究中基于人群的心血管影像学。我们将评估CMR协议、可行性、工艺优化和成本。还介绍了意外发现、质量控制和数据处理和分析的程序。与英国生物银行资源中的所有其他数据一样，该图像和相关信息数据库将通过英国生物银行的访问程序提供给研究人员（无论其原籍国，无论他们是学术人员还是商业人员），用于符合公共利益的健康相关研究。
UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3–4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank’s dedicated bespoke imaging centres, it is proposed that 15–20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5–6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank’s Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest.