P300 event-related potential heritability in monozygotic and dizygotic twins.
P300 event-related potential heritability in monozygotic and dizygotic twins.
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DOI：
10.1111/j.1469-8986.1997.tb02415.x
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发表时间：
1997
期刊：
影响因子：
3.7
通讯作者：
J. Katsanis;W. Iacono;M. McGue;S. R. Carlson
中科院分区：
文献类型：
--
作者：
J. Katsanis;W. Iacono;M. McGue;S. R. Carlson
本研究通过对30对同卵双生子（MZ）和34对异卵双生子（DZ）的视觉事件相关电位（ERP）的测定，探讨了P3波和N1、P2、N2波的遗传率。脑电图活动记录从Pz，P3和P4头皮网站，而个人进行的反应时间任务，涉及两种条件不同的难度。遗传建模表明，实质性的遗传影响P3振幅，P3潜伏期，和手动反应时间的困难条件。在简单条件下，P3潜伏期和手反应时的遗传力不显著，但P3波幅的遗传力显著。早期成分（N1，P2和N2）的振幅是可遗传的，但没有显着的遗传影响，发现这些组件的潜伏期。与DZ双胞胎相比，MZ对事件相关电位测量的更大相似性并不是因为他们在头部尺寸或心理能力方面的更大相似性，尽管事实上IQ分数与P3和N2振幅弱相关，并且振幅和潜伏期与头部尺寸的某些测量相关。这些研究结果表明，P3振幅和早期ERP组件的振幅部分遗传控制下，支持的概念，这些ERP组件可能被用来识别精神病理学的遗传风险。
The present study examined the heritability of the P3 waveform and the N1, P2, and N2 components by assessing the visual event-related potential (ERP) of 30 monozygotic (MZ) and 34 dizygotic (DZ) twin pairs. Electroencephalogram activity was recorded from Pz, P3, and P4 scalp sites while individuals performed a reaction time task involving two conditions differing in difficulty. Genetic modeling indicated substantial genetic influence on P3 amplitude, P3 latency, and manual reaction time for the difficult condition. No significant heritability was found for the latency of P3 or manual reaction time for the easy condition, but P3 amplitude was heritable for this condition. The amplitude of the early components (N1, P2, and N2) was heritable, but no significant genetic influences were found for the latency of these components. Compared with the DZ twins, the greater similarity of the MZ pairs on the event-related potential measures was not due to their greater similarity in either head dimensions or mental ability, despite the facts that IQ scores were weakly correlated with P3 and N2 amplitude and that amplitude and latency were related to some measures of head size. These findings suggest that P3 amplitude and the amplitude of earlier ERP components are under partial genetic control, supporting the notion that these ERP components could perhaps be used to identify genetic risk for psychopathology.