Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate.
Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate.
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DOI：
10.7554/elife.65682
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发表时间：
2021-10-21
期刊：
影响因子：
7.7
通讯作者：
Giorgi E
中科院分区：
文献类型：
--
作者：
Amoah B;McCann RS;Kabaghe AN;Mburu M;Chipeta MG;Moraga P;Gowelo S;Tizifa T;van den Berg H;Mzilahowa T;Takken W;van Vugt M;Phiri KS;Diggle PJ;Terlouw DJ;Giorgi E
监测疟疾传播是实现消除和根除目标努力的关键组成部分。传播强度的两个常用监测指标是寄生虫流行率（PR）和昆虫接种率（EIR）。比较某一地理区域的疟疾流行率和疟疾感染率的时空变化，并对这两个指标之间的关系进行建模，可以更全面地了解该区域的疟疾流行病学情况，从而为防治活动提供信息。利用地理统计学方法，我们比较了恶性疟原虫EIR和PR的时空格局，使用了在马拉维农村地区收集的38个月的数据。然后，我们通过使用经验和机制统计模型来量化EIR和PR之间的关系。通过EIR和PR确定的热点在高传播季节部分重叠，而在低传播季节则不重叠。估计的关系表明，EIR对PR的影响延迟了1个月，因此在较低的EIR水平下，EIR的增加与PR的快速上升相关，而在较高的EIR水平下，EIR的变化不会转化为PR的显著变化。我们的研究强调需要综合疟疾控制策略，将媒介和人类宿主管理结合起来，由昆虫学和寄生虫病指数监测。本研究得到《缝纫日记》资助号13050800。
Monitoring malaria transmission is a critical component of efforts to achieve targets for elimination and eradication. Two commonly monitored metrics of transmission intensity are parasite prevalence (PR) and the entomological inoculation rate (EIR). Comparing the spatial and temporal variations in the PR and EIR of a given geographical region and modelling the relationship between the two metrics may provide a fuller picture of the malaria epidemiology of the region to inform control activities. Using geostatistical methods, we compare the spatial and temporal patterns of Plasmodium falciparum EIR and PR using data collected over 38 months in a rural area of Malawi. We then quantify the relationship between EIR and PR by using empirical and mechanistic statistical models. Hotspots identified through the EIR and PR partly overlapped during high transmission seasons but not during low transmission seasons. The estimated relationship showed a 1-month delayed effect of EIR on PR such that at lower levels of EIR, increases in EIR are associated with rapid rise in PR, whereas at higher levels of EIR, changes in EIR do not translate into notable changes in PR. Our study emphasises the need for integrated malaria control strategies that combine vector and human host managements monitored by both entomological and parasitaemia indices. This work was supported by Stichting Dioraphte grant number 13050800.
影响因子：
3.7
作者：
Sesay SSS;Giorgi E;Diggle PJ;Schellenberg D;Lalloo DG;Terlouw DJ
通讯作者：
Terlouw DJ