Saccadometry: a new tool for evaluating presymptomatic Huntington patients
Saccadometry: a new tool for evaluating presymptomatic Huntington patients
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DOI：
10.1097/wnr.0b013e32821c560d
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发表时间：
2007-07-16
期刊：
影响因子：
1.7
通讯作者：
Carpenter, Roger
中科院分区：
文献类型：
--
作者：
Antoniades, Chrystalina A.;Altham, Pat M. E.;Carpenter, Roger
扫视反应时间或潜伏期反映了决定看哪里的主要皮层机制的运作。潜伏期的一个不寻常的特征是，它在不同的试验中随机变化。在过去，这种变化一直被认为是一个讨厌的，但分析其统计特性已被证明提供了更多的洞察到潜在的大脑决策机制。由于最近的技术进步，可以使用微型便携式设备快速和非侵入性地收集大量数据，从而提供了使用扫视测量作为生物标志物来增强神经系统疾病的诊断和监测的可能性。在这里，我们表明，这种技术可以强大的区分基因识别的前驱和症状性亨廷顿舞蹈病患者与年龄匹配的控制，主要是通过异常早期反应的数量增加，这可能反映了损害的紧张性抑制的丘通常介导的途径通过基底神经节。
Saccadic reaction time or latency reflects the operation of the largely cortical mechanisms that decide where to look. An unusual feature of latency is that it varies randomly from trial to trial. In the past, this variation has been regarded as a nuisance, but analysis of its statistical properties has turned out to provide much insight into the underlying cerebral decision mechanisms. Thanks to recent technological improvements, large number of data can be gathered quickly and noninvasively using miniature, portable devices, offering the possibility of using saccadometry as a biomarker to enhance the diagnosis and monitoring of neurological conditions. Here we show that this technique can robustly distinguish genetically identified presymptomatic and symptomatic Huntington's disease patients from age-matched controls, largely through an increase in the number of unusually early responses, which might reflect an impairment of the tonic suppression of the colliculus normally mediated by pathways through the basal ganglia.