Dopamine D2 receptors are organized in bands in normal human temporal cortex
Dopamine D2 receptors are organized in bands in normal human temporal cortex
复制标题
DOI：
10.1016/0306-4522(96)00132-7
复制
发表时间：
1996-09-01
期刊：
影响因子：
3.3
通讯作者：
Joyce, JN
中科院分区：
文献类型：
--
作者：
Goldsmith, SK;Joyce, JN
先前的研究表明，多巴胺D2受体在人类海马、嗅内皮层和嗅周围皮层中具有高度区隔和层状组织。这些区域接收来自颞上沟和颞下沟的多感觉联合皮层区域的输入，这些区域证明了其他技术识别的功能模块。我们检查了颞叶等皮质区域D2受体表达的分化模式，正如在他们的古皮层颞叶目标中观察到的那样。利用定量放射自显影技术，我们在正常人类颞叶皮层的喙端-尾端范围内发现了高浓度多巴胺D2受体的三维带组织。在冠状面，这些富含D2受体的带呈柱状，带内D2受体的浓度几乎是邻近皮质的两倍。这些富含D2受体的条带具有明显的层状外观，颗粒细胞层上缺乏与D2受体结合的[I-125]表皮蛋白，III和V层的D2受体浓度高于紧邻的皮层。它们在冠状面具有一致的宽度（平均宽度为2.83 +/- 0.62 mm），但在背掌面具有长轴（有些长度至少为2500 μ m）。因此，它们以富含D2受体和缺乏D2受体的三维模块的形式存在，它们的长轴位于背掌面。酪氨酸羟酶免疫反应纤维与D2受体富集带的长轴呈正交交叉。其他单胺受体（β -肾上腺素能、5-羟色胺(2)）和髓磷脂（抗髓磷脂碱性蛋白免疫组化）、胶质（5′-核苷酸酶）和能量代谢（细胞色素氧化酶）的标记物显示层流组织，但未能划分D2受体富集带。这些富含D2受体的条带大部分出现在颞上回的外侧和下侧，较少出现在颞下回的外侧表面和海马旁皮层（Brodmann’s area 22, 42和20,21,37）。它们在初级听觉皮层中缺失（Brodmann's 41）。目前的研究是第一次观察到突触元件的模块化组织，由D2受体识别，在任何物种的非初级感觉皮层。多巴胺D2受体富集带位于先前确定的具有功能模块的区域，这些功能模块是特征提取的基础。因此，富含D2受体和缺乏D2受体的模块可能提供了多巴胺对这些区域内隔室的功能调节机制。版权所有IBRO。Elsevier Science Ltd.出版。
Previous studies have documented a highly compartmentalized and laminar organization of dopamine D2 receptors in human hippocampus, entorhinal and perirhinal cortices. These areas receive input From regions of polysensory association cortices of the superior and inferior temporal sulci that evidence Functional modules identified by other techniques. We examined the isocortical regions of temporal lobe for an equally well-differentiated pattern of D2 receptor expression as observed in their paleocortical temporal lobe targets. Using quantitative autoradiography we identified an organization of three-dimensional bands of high concentrations of dopamine D2 receptors throughout the rostral-caudal extent of the normal human temporal cortex. In the coronal plane, these D2 receptor-enriched bands had a columnar appearance with the concentration of D2 receptors almost two-fold higher within the bands than in the immediately adjacent cortex. These D2 receptor-enriched bands had a distinct laminar appearance with a paucity of [I-125]epidepride binding to D2 receptors over the granule cell layer and higher concentrations of D2 receptors in laminae III and V than in the immediately adjacent cortex. They had a consistent width (mean width of 2.83 +/- 0.62 mm) in the coronal plane, but had their long axes in the rostrocaudal plane (some were al least 2500 mu m in length). Hence, they exist as three-dimensional D2 receptor-enriched and receptor-poor modules with their long axes in the rostrocaudal plane. Tyrosine hydroxylase-immunoreactive fibers were observed to cross orthogonally to the long axes of the D2 receptor enriched bands. Other monoamine receptors (beta-adrenergic, 5-hydroxytryptamine(2), and markers for myelin (anti-myelin basic protein immunohistochemistry), glia (5'-nucleotidase), and energy metabolism (cytochrome oxidase) showed a laminar organization but failed to demarcate the D2 receptor-enriched bands. The majority of these D2 receptor-enriched bands were observed in the lateral and inferior aspects of the superior temporal gyrus, less frequently on the lateral surface of the inferior temporal gyrus and the parahippocampal cortices (Brodmann's area 22, 42 and 20, 21, 37). They were absent from primary auditory cortex (Brodmann's 41).The present study is the first known observation of a modular organization of synaptic elements, identified by D2 receptors, in non-primary sensory cortices of any species. The dopamine D2 receptor-enriched bands were found in regions previously identified as having functional modules that underlie feature extraction. Hence, D2 receptor-enriched and receptor-poor modules may provide a mechanism for functional regulation of compartments within these regions by dopamine. Copyright (C) 1996 IBRO. Published by Elsevier Science Ltd.