Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
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DOI：
10.1513/annalsats.201312-429ld
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发表时间：
2014-04-01
影响因子：
8.3
通讯作者：
Martinez, Fernando J
中科院分区：
文献类型：
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作者：
Rosas, Ivan O;Dellaripa, Paul F;Martinez, Fernando J
尚未开展跨越数十年、以人群为基础的纵向研究，将儿童期、青春期和成年早期的危险因素与成年晚期临床间质性肺疾病 (ILD) 事件联系起来。此外，尚未进行观察性或随机临床试验；因此，目前没有证据支持生命早期危险因素水平降低可以预防成年后ILD事件的观点。一级预防策略是针对宿主的干预措施，旨在改变不良危险因素（即吸烟），以预防 ILD 的发展，而 ILD 的初级预防可以定义为消除外部风险因素（即环境污染物）。由于以前没有进行过 ILD 一级预防研究，我们建议，随着时间的推移，促进一级预防策略实施的研究可以使 ILD 的一部分变得可预防。在此，我们提供了未来实施预防战略所需的一些初步步骤；本声明讨论了支持初级预防和一级预防的潜在机会的基本原理和现有证据，以及未来 ILD 预防性干预研究的沃土。
Population-based, longitudinal studies spanning decades linking risk factors in childhood, adolescence and early adulthood to incident clinical interstitial lung disease (ILD) events in late adulthood have not been performed. In addition, no observational or randomized clinical trials have been conducted; therefore, there is presently no evidence to support the notion that reduction of risk factor levels in early life prevents ILD events in adult life. Primary prevention strategies are host-directed interventions designed to modify adverse risk factors (i.e., smoking) with the goal of preventing the development of ILD, whereas primordial prevention for ILD can be defined as the elimination of external risk factors (i.e., environmental pollutants). As no ILD primary prevention studies have been previously conducted, we propose that research studies that promote implementation of primary prevention strategies could, over time, make a subset of ILD preventable. Herein, we provide a number of initial steps required for the future implementation of prevention strategies; this statement discusses the rationale and available evidence that support potential opportunities for primordial and primary prevention, as well as fertile areas for future research of preventive intervention in ILD.