Childhood Trauma and Personality Disorder Criterion Counts: A Co-twin Control Analysis
Childhood Trauma and Personality Disorder Criterion Counts: A Co-twin Control Analysis
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DOI：
10.1037/a0034238
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发表时间：
2013-11-01
影响因子：
4.6
通讯作者：
Kendler, Kenneth S.
中科院分区：
文献类型：
--
作者：
Berenz, Erin C.;Amstadter, Ananda B.;Kendler, Kenneth S.
相关性研究一致报告儿童期创伤（CT）和大多数人格障碍（PD）标准和诊断之间的关系。然而，目前尚不清楚CT是否与PD直接相关，或者常见的家族因素（即，共同的环境和/或遗传因素）更好地解释了这种关系。本研究采用双胞胎对照设计，以检查CT对PD标准计数的直接影响的支持。参与者来自挪威双胞胎登记处（N = 2，780），包括一个双胞胎对子集（n = 898）（449对，45%为单卵[MZ]），CT符合DSM-IV创伤后应激障碍标准A。所有参与者都完成了挪威版的DSM-IV人格结构化面试。在一般样本中检测到CT和所有PD标准计数之间的显著相关性;然而，观察到的效应幅度很小，CT占PD标准计数方差的比例不超过约1%。一个显着的，但温和的，交互作用的性别和CT检测到分裂样和分裂型PD标准计数，与CT与这些疾病的女性，但不是男性。在不一致双胞胎样本中考虑了常见的家族因素后，CT与边缘和反社会PD标准计数显著相关，但与其他疾病无关;然而，观察到的影响程度相当适度（两种结果的r（2）= 0.006），表明在全样本中观察到的小影响可能更好地由常见的遗传和/或环境因素解释。CT似乎不是PD病因的关键因素。
Correlational studies consistently report relationships between childhood trauma (CT) and most personality disorder (PD) criteria and diagnoses. However, it is not clear whether CT is directly related to PDs or whether common familial factors (i.e., shared environment and/or genetic factors) better account for that relationship. The current study used a co-twin control design to examine support for a direct effect of CT on PD criterion counts. Participants were from the Norwegian Twin Registry (N = 2,780), including a subset (n = 898) of twin pairs (449 pairs, 45% monozygotic [MZ]) discordant for CT meeting DSM-IV Posttraumatic Stress Disorder Criterion A. All participants completed the Norwegian version of the Structured Interview for DSM-IV Personality. Significant associations between CT and all PD criterion counts were detected in the general sample; however, the magnitude of observed effects was small, with CT accounting for no more than approximately 1% of variance in PD criterion counts. A significant, yet modest, interactive effect was detected for sex and CT on Schizoid and Schizotypal PD criterion counts, with CT being related to these disorders among women but not men. After common familial factors were accounted for in the discordant twin sample, CT was significantly related to Borderline and Antisocial PD criterion counts, but no other disorders; however, the magnitude of observed effects was quite modest (r(2) = .006 for both outcomes), indicating that the small effect observed in the full sample is likely better accounted for by common genetic and/or environmental factors. CT does not appear to be a key factor in PD etiology.