A Brief Computerized Paired Associate Test for the Detection of Mild Cognitive Impairment in Community-Dwelling Older Adults.
A Brief Computerized Paired Associate Test for the Detection of Mild Cognitive Impairment in Community-Dwelling Older Adults.
复制标题
用于检测社区老年人轻度认知障碍的简短计算机配对测试。
DOI：
10.3233/jad-160370
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发表时间：
2016-09-06
期刊：
影响因子：
--
通讯作者：
Loewenstein DA
中科院分区：
文献类型：
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作者：
Curiel RE;Crocco E;Rosado M;Duara R;Greig MT;Raffo A;Loewenstein DA
语义记忆干扰被认为是早期AD的预测性认知标志。这是相关的，因为开发评估范式来识别微妙的认知和功能缺陷是临床前阿尔茨海默病研究的优先事项。探讨一种新型计算机配对联想测验在区分社区老年人轻度认知障碍（MCI）和认知正常（CN）人群中的实用性。CN（n = 64）或MCI（n = 34）的参与者进行了迈阿密语义干扰和学习测试（MITSI-L）。这种新的仪器是一个简短的，计算机化的配对关联测试，测量强度的记忆绑定的语义相关的单词对，并引入了一个积极的语义干扰条件，要求参与者之间的语义相似的目标，使不同的协会。一系列方差分析探讨了MITSI-L性能的差异。Logistic回归和受试者工作曲线（ROC）分析，以进一步确定区分效度。MCI参与者在所有指标上的得分均低于CN老年人。两个子评分的复合正确分类MCI的85.3%和CN参与者的84.4%。ROC下的面积相对于MMSE、通道的即时记忆和敏感记忆测量LASSI-L的几个子测试更高。MITSI-L是一种计算机化测试，可以成功区分MCI和CN参与者。ROC曲线下面积超过了整体精神状态和其他记忆指标。MITSI-L在检测MCI方面的有效性，以及其简单的管理和便携性使其值得进一步研究。
Semantic memory interference has been found to be a predictive cognitive marker of incipient AD. This is relevant given that developing assessment paradigms to identify subtle cognitive and functional deficits is a priority in preclinical Alzheimer’s disease research. To examine the utility of a novel computerized paired associate test in distinguishing between mild cognitive impairment (MCI) and cognitively normal (CN) groups of older adults residing in the community. Participants that were CN (n = 64) or MCI (n = 34) were administered the Miami Test of Semantic Interference and Learning (MITSI-L). This novel instrument is a brief, computerized paired associate test that measured the strength of memory binding of semantically related word pairs and introduced a proactive semantic interference condition which required participants to make different associations between semantically similar targets. A series of ANOVAs explored differences on MITSI-L performance. Logistic regression and receiver operator curves (ROC) analyses were employed to further determine discriminative validity. MCI participants had lower scores on all indices relative to CN elders. A composite of two subscores correctly classified 85.3% of MCI and 84.4% of CN participants. Area under the ROC was higher relative to the MMSE, immediate memory for passages, and several subtests of a sensitive memory measure, the LASSI-L. The MITSI-L is a computerized test that can successfully differentiate MCI from CN participants. Area under the ROC curve exceeded that of global mental status and other memory measures. The effectiveness of the MITSI-L in detecting MCI, and its brief administration and portability render it worthy of further research.