ACAP1 promotes endocytic recycling - Short article by recognizing recycling sorting signals
ACAP1 promotes endocytic recycling - Short article by recognizing recycling sorting signals
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DOI：
10.1016/j.devcel.2004.10.002
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发表时间：
2004-11-01
影响因子：
11.8
通讯作者：
Hsu, VW
中科院分区：
文献类型：
--
作者：
Dai, J;Li, J;Hsu, VW
已经预测促进货物蛋白从膜隔室运输的货物分选在内吞再循环途径中是不可能的。我们现在表明，ACAP1特异性和直接结合到回收货物蛋白。减少TfR的这种相互作用会抑制其再循环。此外，ACAP1结合到TfR的胞质结构域中的两个不同的基于苯丙氨酸的序列，其作为再循环分选信号起作用以促进其从再循环内体的转运。综上所述，这些发现表明，ACAP1通过识别回收分拣信号来促进货物分拣。
Cargo sorting that promotes the transport of cargo proteins from a membrane compartment has been predicted to be unlikely in the endocytic recycling pathways. We now show that ACAP1 binds specifically and directly to recycling cargo proteins. Reducing this interaction for TfR inhibits its recycling. Moreover, ACAP1 binds to two distinct phenylalanine-based sequences in the cytoplasmic domain of TfR that function as recycling sorting signals to promote its transport from the recycling endosome. Taken together, these findings indicate that ACAP1 promotes cargo sorting by recognizing recycling sorting signals.