The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART
The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART
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DOI：
10.1097/qad.0b013e3282efb74b
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发表时间：
2007-10-01
期刊：
影响因子：
3.8
通讯作者：
Cahn, Pedro
中科院分区：
文献类型：
--
作者：
Belmonte, Liliana;Olmos, Martin;Cahn, Pedro
在44例HIV-1阳性患者中评价了远端十二指肠粘膜中HIV-1 RNA的存在。在未接受过抗逆转录病毒治疗且血浆病毒载量较高的患者、接受HAART且血浆病毒载量低于检测限的患者以及接受HAART且病毒学失败的患者的肠道组织中检测到HIV-1 RNA。肠粘膜似乎是一个受血浆病毒载量或HAART水平影响很小的储库。
The presence of HIV-1 RNA in distal duodenal mucosa was evaluated in 44 HIV-1-positive patients. HIV-1 RNA was detected in gut tissue in antiretroviral-naive patients with high plasma viral loads, as well as in patients on HAART with plasma viral loads below the limit of detection and in patients on HAART with virological failure. The intestinal mucosa seems to serve as a reservoir poorly influenced by levels of plasma viral load or HAART.