Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer?
Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer?
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DOI：
10.1016/j.bihy.2008.06.003
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Zheng, Tongzhang
中科院分区：
文献类型：
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作者：
Zhang, Yawei;Guo, Grace L;Zheng, Tongzhang
在过去的几十年里，包括美国在内的世界许多地方都报道了甲状腺癌发病率的增加。最近出现的证据表明，多卤芳烃（PHAHs），特别是多溴联苯醚（PBDEs），改变甲状腺激素稳态并导致甲状腺功能障碍。然而，很少有研究测试暴露于多溴二苯醚和其他多环芳烃是否会增加患甲状腺癌的风险。在这里，我们假设高暴露于多溴二苯醚，特别是多溴二苯醚，增加甲状腺癌的风险，并可能解释过去几十年来甲状腺癌发病率增加的部分原因。此外，代谢途径基因的遗传和表观遗传变异可能会改变参与内源性甲状腺激素代谢和多溴二苯醚等多环芳烃解毒的代谢酶的表达和功能。这种变异可能导致个体对多溴二苯醚和其他多环芳烃的易感性不同，进而导致甲状腺癌的发展。对这一假说的研究将有助于更好地了解多溴二苯醚和其他多环芳烃在甲状腺肿瘤发生中的作用，并可能为预防这一致命疾病提供真正的手段。
An increased incidence of thyroid cancer has been reported in many parts of the world including the United States during the past several decades. Recently emerging evidence has demonstrated that polyhalogenated aromatic hydrocarbons (PHAHs), particularly polybrominated diphenyl ethers (PBDEs), alter thyroid hormone homeostasis and cause thyroid dysfunction. However, few studies have been conducted to test whether exposure to PBDEs and other PHAHs increases the risk of thyroid cancer. Here, we hypothesize that elevated exposure to PHAHs, particularly PBDEs, increases the risk of thyroid cancer and may explain part of the increase in incidence of thyroid cancer during the past several decades. In addition, genetic and epigenetic variations in metabolic pathway genes may alter the expression and function of metabolic enzymes which are involved in the metabolism of endogenous thyroid hormones and the detoxification of PBDEs and other PHAHs. Such variation may result in different individual susceptibilities to PBDEs and other PHAHs and the subsequent development of thyroid cancer. The investigation of this hypothesis will lead to an improved understanding of the role of PBDEs and other PHAHs in thyroid tumorigenesis and may provide a real means to prevent this deadly disease.