Effect of onion and beet on plasma and liver lipids, platelet aggregation, and erythrocyte Na efflux in simvastatin treated hypercholesterolmic rats.
Effect of onion and beet on plasma and liver lipids, platelet aggregation, and erythrocyte Na efflux in simvastatin treated hypercholesterolmic rats.
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DOI：
10.4162/nrp.2008.2.4.211
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发表时间：
2008
影响因子：
2.4
通讯作者：
Kang JS
中科院分区：
文献类型：
--
作者：
Kim JL;Chae IS;Kang YH;Kang JS
本研究的目的是探讨洋葱或甜菜对辛伐他汀 (SIM) 治疗的高胆固醇血症大鼠血浆和肝脏脂质、红细胞 Na 流出通道和血小板聚集的影响。将 40 只 Sprague Dawley 大鼠分为四组，饲喂含有 2 mg/kg BW 辛伐他汀或辛伐他汀加 5% 洋葱或甜菜粉的 0.5% 胆固醇饮食。与对照组相比，SIM组血浆总胆固醇显着升高（p<0.01），SIM组升高的血浆总胆固醇在SIM-洋葱组和SIM-甜菜组中显着降低（p<0.05）。 SIM-甜菜组的HDL-胆固醇与其他组相比显着升高（p<0.05）。与SIM-洋葱组相比，SIM组的血小板聚集的最大斜率和初始斜率均显着降低（p<0.05）。与对照组、SIM-洋葱组和SIM-甜菜组相比，SIM组Na-K ATP酶显着降低（p<0.05）。与对照组相比，使用 SIM 治疗的所有组中 Na 被动渗漏均显着增加 (p<0.05)。 SIM组总Na流出量减少，SIM-洋葱组总Na流出量增加，两组之间差异有显着性（p<0.05）。各组间细胞内Na没有差异。在本研究中，HMG CoA还原酶抑制剂辛伐他汀在剂量为2mg/kg BW/天时相当增加大鼠血浆总胆固醇，推测辛伐他汀对大鼠和人类胆固醇代谢的作用机制不同。在 SIM 治疗的大鼠中，洋葱和甜菜通过 Na-K ATP 酶和 Na-K 共转运恢复减少的 Na 流出，从而在心血管系统中发挥有利作用。
This study was purposed to investigate the effect of onion or beet on plasma and liver lipids, erythrocyte Na efflux channels and platelet aggregation in simvastatin (SIM) treated hypercholesterolemic rats. Forty Sprague Dawley rats were divided into four groups and fed 0.5% cholesterol based diets containing 2 mg/kg BW simvastatin or simvastatin with 5% onion or beet powder. Plasma total cholesterol was significantly increased in SIM group compared with the control (p<0.01), and the elevated plasma total cholesterol of SIM group was significantly decreased in SIM-onion and SIM-beet groups (p<0.05). HDL-cholesterol in SIM-beet group was significantly increased compared with other groups (p<0.05). Platelet aggregation in both the maximum and initial slope was significantly decreased in SIM group compared with SIM-onion group (p<0.05). Na-K ATPase was significantly decreased in SIM group compared with the control, SIM-onion and SIM-beet groups (p<0.05). Na passive leak was significantly increased in all groups treated with SIM compared with the control (p<0.05). The total Na efflux was decreased in SIM group and increased in SIM-onion group and the difference between these two groups was significant (p<0.05). There was no difference in intracellular Na among groups. In present study, simvastatin, a HMG CoA reductase inhibitor at dose of 2mg/kg BW/day rather increased plasma total cholesterol in rats, inferring that the action mechanism of simvastatin on cholesterol metabolism differ between rat and human. Onion and beet play favorable roles in cardiovascular system by restoring the reduced Na efflux through Na-K ATPase and Na-K cotransport in SIM treated rats.