The role of Computer Aided Process Engineering in physiology and clinical medicine
The role of Computer Aided Process Engineering in physiology and clinical medicine
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DOI：
10.1016/j.compchemeng.2009.10.021
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发表时间：
2010-05-10
影响因子：
4.3
通讯作者：
Sumner, Tom
中科院分区：
文献类型：
--
作者：
Bogle, I. David L.;Allen, Richard;Sumner, Tom
本文讨论了计算机辅助过程工程（CAPE）在开发工程分析和设计方法的生物系统的多层次细胞信号网络，基因，蛋白质和代谢网络，细胞系统，通过生理系统的潜在作用。21世纪生命科学面临的挑战是将广泛分散的模型和知识汇集在一起，以便能够对这些复杂系统进行全系统的理解。这种系统水平的理解应该具有广泛的临床益处。计算机辅助过程工程可以带来系统的方法，以（i）提高对这些复杂的化学和物理过程的理解，（特别是复杂流动状态下的分子输运）在生命系统中多尺度的相互作用，（ii）分析这些模型，以帮助确定关键的缺失信息，并探索系统扰动对主要输出变量的影响，以及（iii）在体内系统中“设计”潜在的干预措施，这些干预措施可能具有需要理解的显著有益或潜在有害的影响。本文开发了这三个主题在伦敦大学学院最近的项目。第一个项目模拟了血流对动脉内皮细胞的影响，考虑到细胞形状的变化导致细胞骨架的变化，从而导致随后的化学变化。第二个项目是建立人类肝脏的计算机模型，将分子水平的模型与肝脏联系在一起。复合模型模拟肝脏和相关器官中的葡萄糖调节。这两个项目都涉及分子传输、化学反应和复杂的多尺度系统，CAPE的方法可以解决这些问题。化学工程师解决制造过程中的多尺度问题-从分子尺度到单元操作尺度，再到工厂和企业范围的系统-因此，他们拥有与生命科学家和临床科学家合作解决生理学和临床医学问题的适当技能。(C)2009爱思唯尔有限公司版权所有。
This paper discusses the potential role for Computer Aided Process Engineering (CAPE) in developing engineering analysis and design approaches to biological systems across multiple levels cell signalling networks, gene, protein and metabolic networks, cellular systems, through to physiological systems. The 21st Century challenge in the Life Sciences is to bring together widely dispersed models and knowledge in order to enable a system-wide understanding of these complex systems. This systems level understanding should have broad clinical benefits. Computer Aided Process Engineering can bring systems approaches to (i) improving understanding of these complex chemical and physical (particularly molecular transport in complex flow regimes) interactions at multiple scales in living systems, (ii) analysis of these models to help to identify critical missing information and to explore the consequences on major output variables resulting from disturbances to the system, and (iii) 'design' potential interventions in in vivo systems which can have significant beneficial, or potentially harmful, effects which need to be understood. This paper develops these three themes drawing on recent projects at UCL. The first project has modeled the effects of blood flow on endothelial cells lining arteries, taking into account cell shape change resulting in changes in the cell skeleton which cause consequent chemical changes. A second is a project which is building an in silico model of the human liver, tieing together models from the molecular level to the liver. The composite model models glucose regulation in the liver and associated organs. Both projects involve molecular transport, chemical reactions, and complex multiscale systems, tackled by approaches from CAPE.Chemical Engineers solve multiple scale problems in manufacturing processes - from molecular scale through unit operations scale to plant-wide and enterprise wide systems - so have an appropriate skill set for tackling problems in physiology and clinical medicine, in collaboration with life and clinical scientists. (C) 2009 Elsevier Ltd. All rights reserved.