Prevalence of pulmonary hypertension in hereditary spherocytosis
Prevalence of pulmonary hypertension in hereditary spherocytosis
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DOI：
10.1002/ajh.22182
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发表时间：
2011-12-01
影响因子：
12.8
通讯作者：
Buchanan, George R.
中科院分区：
文献类型：
--
作者：
Crary, Shelley E.;Ramaciotti, Claudio;Buchanan, George R.
Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders, including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy) utilizing echocardiography to estimate tricuspid regurgitant jet velocity (TRV) as well as measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) to screen for PH. No participant with HS had a significantly elevated TRV or NT-proBNP level, despite a median 25-year interval since splenectomy (95% confidence interval for point prevalence 0, 0.097). Although our study was limited by a small sample size, it appears that persons with HS, following splenectomy, appear unlikely to be at significantly increased risk of developing PH to the degree reported for thalassemia and sickle cell disease.
