Ephaptic Coupling as a Resolution to the Paradox of Action Potential Wave Speed and Discordant Alternans Spatial Scales in the Heart.
Ephaptic Coupling as a Resolution to the Paradox of Action Potential Wave Speed and Discordant Alternans Spatial Scales in the Heart.
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DOI：
10.1103/physrevlett.130.218401
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发表时间：
2023-05-26
影响因子：
8.6
通讯作者：
Weinberg, Seth H.
中科院分区：
文献类型：
--
作者：
Otani, Niels F.;Figueroa, Eileen;Garrison, James;Hewson, Michelle;Munoz, Laura;Fenton, Flavio H.;Karma, Alain;Weinberg, Seth H.
以前的计算机模拟表明，现有的心脏动作电势波传播模型与观察到的波传播行为并不一致。具体地说，计算机模型不能同时再现在同一模拟中实验测量的不协调交替模式的快速波速和小空间尺度。这种差异很重要，因为不和谐的交替可能是心脏出现异常和危险的快速心律的关键先兆。在这封信中，我们证明了这一悖论可以通过允许所谓的触觉耦合代替传统的缝隙-结耦合在波前传播中发挥主要作用来解决。有了这种修正，生理波速和小的不协调交替空间尺度都出现在缝隙结阻值上，这与实验中观察到的值更一致。因此，我们的理论也支持触觉耦合在正常波传播中起重要作用的假说。
Previous computer simulations have suggested that existing models of action potential wave propagation in the heart are not consistent with observed wave propagation behavior. Specifically, computer models cannot simultaneously reproduce the rapid wave speeds and small spatial scales of discordant alternans patterns measured experimentally in the same simulation. The discrepancy is important, because discordant alternans can be a key precursor to the development of abnormal and dangerous rapid rhythms in the heart. In this Letter, we show that this paradox can be resolved by allowing so-called ephaptic coupling to play a primary role in wave front propagation in place of conventional gap-junction coupling. With this modification, physiological wave speeds and small discordant alternans spatial scales both occur with gap-junction resistance values that are more in line with those observed in experiments. Our theory thus also provides support to the hypothesis that ephaptic coupling plays an important role in normal wave propagation.
影响因子：
3.7
作者：
Sato D;Bers DM;Shiferaw Y
通讯作者：
Shiferaw Y