Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.
Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺疾病急性加重期肺康复的有效性和安全性。
DOI：
10.12659/msm.892769
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发表时间：
2015-03-18
期刊：
影响因子：
--
通讯作者：
Qiu, Zhongmin
中科院分区：
文献类型：
--
作者：
He, Mei;Yu, Sue;Qiu, Zhongmin
背景：肺康复（PR）能够改善慢性阻塞性肺疾病（COPD）患者的呼吸困难、耐力能力和健康相关的生活质量，但在中国很少使用。本研究旨在评估 COPD 恶化后 PR 的有效性和安全性。 材料和方法：因 COPD 恶化而入院的患者被随机分配接受 PR 或常规护理（对照组）。 PR 计划从入院第二天一直进行到出院。确定6分钟步行距离（6MWD）的前后变化、通过CAT评分和CRQ-SAS评分评估的自我报告的生活质量（QOL）以及通过ADL-D评分评估的日常生活活动。在整个研究过程中测量了感觉到的用力末期呼吸困难（Borg 量表）。 结果：共有 101 名患者入组，其中 7 名患者在随机分组后退出，94 名患者完成了本研究。 PR组有66名患者，对照组有28名患者。 PR 组的 6MWD、静息 SpO2 和运动 Borg 呼吸困难评分均显着改善。此外，PR 组 CRQ-SAS 总分改善较大，CAT 得分较低。 PR 组的 ADL-D 和 BODE 指数也有显着改善。运动期间没有记录到不良事件。结论：我们的研究提供的证据表明，对 COPD 急性加重患者应用早期 PR 是安全可行的。
BACKGROUND: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance capacity, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients, but it is rarely used in China. This study aimed to assess the effectiveness and safety of PR after exacerbation of COPD.MATERIAL AND METHODS: Patients admitted to hospital due to an exacerbation of COPD were randomized to receive either PR or routine care (control group). The PR program was performed from the second day of admission until discharge. The pre-post changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was measured throughout the study.RESULTS: A total of 101 patients were enrolled, of whom 7 withdrew after randomization, and 94 completed this study. There were 66 patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group. In addition, the PR group had greater improvement in the total CRQ-SAS score and had a lower CAT score. Significant improvements were also found in the ADL-D and BODE index in the PR group. No adverse events were recorded during exercise.CONCLUSIONS: Our study provides evidence that it is safe and feasible to apply an early PR in patients with acute exacerbation of COPD.