Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions
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DOI：
10.1016/j.neurobiolaging.2005.09.005
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Frautschy, SA
中科院分区：
文献类型：
--
作者：
Cole, GM;Lim, GP;Frautschy, SA
阿尔茨海默病（AD）和心血管疾病（CVD）是衰老的综合征，具有相似的病变和危险因素。包括脂蛋白氧化损伤和炎症与CVD不同，AD。敏感的生物标志物是未知的，高风险群体研究不足。为了确定AD的潜在预防策略，我们专注于临床前模型（转基因和淀粉样蛋白输注模型），测试流行病学研究中与降低风险密切相关的饮食/生活方式因素。最初，我们报告了非甾体抗炎药（NSAID）的影响，特别是布洛芬。其减少了淀粉样蛋白的积累，但抑制了很少的炎症标记物，并且没有减少氧化损伤。对慢性NSAID的安全性担忧导致了对替代NSAID的筛选，并鉴定了酚类抗炎/抗氧化化合物姜黄素，姜黄中的黄色色素，我们发现其靶向多种AD致病级联反应。饮食中的ω-3脂肪酸，二十二碳六烯酸（DHA），也限制了转基因小鼠模型中的淀粉样蛋白，氧化损伤以及突触和认知缺陷。DHA和姜黄素都具有良好的安全性、流行病学和功效，并且可以发挥一般的抗衰老益处（抗癌和心脏保护）。(c)2005年爱思唯尔公司All rights reserved.
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that share analogous lesions and risk factors. involving lipoproteins, oxidative damage and inflammation. Unlike in CVD, in AD. sensitive biomarkers are unknown, and high-risk groups are understudied. To identify potential prevention strategies in AD, we have focused on pre-clinical models (transgenic and amyloid infusion models), testing dietary/lifestyle factors strongly implicated in reducing risk in epidemiological studies. Initially, we reported the impact of non-steroidal anti-inflammatory drugs (NSAIDs), notably ibuprofen. which reduced amyloid accumulation, but suppressed few inflammatory markers and without reducing oxidative damage. Safety concerns with chronic NSAIDs led to a screen of alternative NSAIDs and identification of the phenolic anti-inflammatory/anti-oxidant compound curcumin, the yellow pigment in turmeric that we found targeted multiple AD pathogenic cascades. The dietary omega-3 fatty acid, docosahexaenoic acid (DHA), also limited amyloid, oxidative damage and synaptic and cognitive deficits in a transgenic mouse model. Both DHA and curcumin have favorable safety profiles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.) (c) 2005 Elsevier Inc. All rights reserved.