Cerebellar dopamine D2 receptors regulate social behaviors
Cerebellar dopamine D2 receptors regulate social behaviors
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小脑多巴胺D2受体调节社会行为
DOI：
10.1038/s41593-022-01092-8
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发表时间：
2022-06-16
影响因子：
25
通讯作者：
Valjent, Emmanuel
中科院分区：
文献类型：
--
作者：
Cutando, Laura;Puighermanal, Emma;Valjent, Emmanuel
小脑是参与控制感觉运动任务的主要大脑结构，也有助于更高的认知功能，包括奖励，情感和社会互动。虽然这些行为的调节在很大程度上归因于边缘区的单胺能系统，小脑多巴胺信号在这些功能的调制中的贡献仍然很大程度上未知。通过结合细胞类型特异性转录组学，组织学分析，三维成像和膜片钳记录，我们证明，小鼠小脑多巴胺D2受体（D2Rs）优先在浦肯野细胞（PC）中表达，并调节PC上的突触功效。此外，我们发现成年期雄性小鼠PC中D2R水平的变化改变了社交能力和对社交新奇事物的偏好，而不影响运动功能。总之，这些发现表明D2R在PC功能中的新作用，并将小脑D2R表达水平与社会行为联系起来。Cutando及其同事表明，小脑浦肯野细胞中D2多巴胺受体水平的变化改变了社交能力和对社会新奇事物的偏好，而不影响运动功能。
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including reward, emotion and social interaction. Although the regulation of these behaviors has been largely ascribed to the monoaminergic system in limbic regions, the contribution of cerebellar dopamine signaling in the modulation of these functions remains largely unknown. By combining cell-type-specific transcriptomics, histological analyses, three-dimensional imaging and patch-clamp recordings, we demonstrate that cerebellar dopamine D2 receptors (D2Rs) in mice are preferentially expressed in Purkinje cells (PCs) and regulate synaptic efficacy onto PCs. Moreover, we found that changes in D2R levels in PCs of male mice during adulthood alter sociability and preference for social novelty without affecting motor functions. Altogether, these findings demonstrate novel roles for D2R in PC function and causally link cerebellar D2R levels of expression to social behaviors.Cutando and colleagues show that changes in D2 dopamine receptor levels in cerebellar Purkinje cells alter sociability and preference for social novelty without affecting motor functions.