DEPENDENCE OF THYMUS DEVELOPMENT ON DERIVATIVES OF THE NEURAL CREST
DEPENDENCE OF THYMUS DEVELOPMENT ON DERIVATIVES OF THE NEURAL CREST
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DOI：
10.1126/science.6606851
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
KIRBY, ML
中科院分区：
文献类型：
--
作者：
BOCKMAN, DE;KIRBY, ML
在9期或10期鸡胚中去除头部神经嵴的局部区域，会显著减小胸腺的大小或导致胸腺缺失。小的胸腺叶包含胸腺细胞和上皮细胞，但发育延迟。甲状旁腺和甲状腺有时体积减小，或在一侧或双侧的正常位置缺失。心脏缺陷一直存在。胸腺的发育可能取决于神经嵴的间充质衍生物与咽上皮的直接相互作用。多种缺陷，比如人类的迪乔治综合征，可能是由于神经嵴衍生物迁移和相互作用不当所致。
Elimination of limited areas of the cephalic neural crest in stage 9 or 10 chick embryos markedly reduced the size of the thymus gland or resulted in its absence. Small thymic lobes contained both thymocytes and epithelial cells but showed delayed development. Parathyroid and thyroid glands sometimes were reduced in size or missing from the normal location on one or both sides. Heart defects were consistently present. Thymus development may depend on direct interaction of mesenchymal derivatives of the neural crest with pharyngeal epithelium. Multiple defects, such as the Di George syndrome [in humans], may result from failure of neural crest derivatives to migrate and interact properly.