Roles of microRNA in prostate cancer cell metabolism
Roles of microRNA in prostate cancer cell metabolism
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DOI：
10.1016/j.biocel.2018.07.003
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发表时间：
2018-09-01
影响因子：
4
通讯作者：
Ignacimuthu, Savarimuthu
中科院分区：
文献类型：
--
作者：
Kasomva, Khanmi;Sen, Arnab;Ignacimuthu, Savarimuthu
MicroRNA 是非编码 RNA，其功能是基因表达的调节因子。 MicroRNA在细胞增殖、细胞周期、细胞代谢、细胞凋亡、侵袭和转移等方面显示出其生物学功能。癌细胞能够通过增加代谢活动在缺乏生长因子的情况下生长。 MicroRNA通过靶向关键酶或转运蛋白来调节细胞代谢过程，并通过干扰癌基因/抑癌基因、缺氧、信号通路和细胞粘附来改变代谢活动。本文主要阐述了microRNA在前列腺癌细胞代谢中的作用，如葡萄糖摄取、糖酵解和乳酸分泌、脂质代谢以及与信号通路的相互作用。还强调了 microRNA 与细胞代谢中缺氧和细胞粘附的关系。因此，miRNA 有助于调节存活肿瘤细胞的代谢，了解这种 miRNA 介导的相互作用可能会为前列腺癌的治疗应用开辟新途径。
MicroRNAs are non-coding RNA which functions as regulators of genes expression. MicroRNAs have shown their biological functions in cell proliferation, cell cycle, cell metabolism, apoptosis, invasion and metastasis. Cancer cells have the ability to grow in the absence of growth factors by increased metabolic activity. MicroRNAs regulate cell metabolic processes by targeting the key enzymes or transporters and change the metabolic activities by interfering with oncogenes/tumor suppressors, hypoxia, signalling pathways and cell adhesion. This review mainly explains the roles of microRNAs in prostate cancer cell metabolism, such as glucose uptake, glycolysis and lactate secretion, lipid metabolism and interaction with signalling pathways. The relation of microRNAs with hypoxia and cell adhesion in cell metabolism is also highlighted. Therefore, miRNAs help in regulating the metabolism of survived tumor cells, understanding such miRNA-mediated interaction could lead to new avenues in therapeutic application to treat PCa.