The CHAOS/DIALIGN WWW server for multiple alignment of genomic sequences
The CHAOS/DIALIGN WWW server for multiple alignment of genomic sequences
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DOI：
10.1093/nar/gkh361
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发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Morgenstern, B
中科院分区：
文献类型：
--
作者：
Brudno, M;Steinkamp, R;Morgenstern, B
跨物种序列比对是分析基因组序列中功能位点的一种强有力的方法，许多发现都是基于基因组比对。在此，我们提出了一个基于www的大型基因组序列多重比对软件系统。我们的服务器利用先前开发的CHAOS和DIALIGN的组合来实现速度和对准精度。CHAOS是一个快速的数据库搜索工具，可以创建一个局部序列相似性列表。这些被DIALIGN用作锚点来加速最终的对齐过程。结果对齐以不同的格式返回给用户，同时返回由CHAOS找到的锚点列表。CHAOS/DIALIGN软件可在http://dialign.gobics.de/chaos-dialign-submission免费获得。
Cross-species sequence comparison is a powerful approach to analyze functional sites in genomic sequences and many discoveries have been made based on genomic alignments. Herein, we present a WWW-based software system for multiple alignment of large genomic sequences. Our server utilizes the previously developed combination of CHAOS and DIALIGN to achieve both speed and alignment accuracy. CHAOS is a fast database search tool that creates a list of local sequence similarities. These are used by DIALIGN as anchor points to speed up the final alignment procedure. The resulting alignment is returned to the user in different formats together with a list of anchor points found by CHAOS. The CHAOS/DIALIGN software is freely available at http://dialign.gobics.de/chaos-dialign-submission.