Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step
Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step
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DOI：
10.1021/ol062777o
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发表时间：
2007-01-18
期刊：
影响因子：
5.2
通讯作者：
Fukase, Koichi
中科院分区：
文献类型：
--
作者：
Tanaka, Katsunori;Motomatsu, Shinya;Fukase, Koichi
[图]在微流控条件下开发了一种高效的脱水方案。该方法被应用于多公斤合成的pristane，这是一种重要的生物学天然产物，现在广泛用作单克隆抗体生产的佐剂。
[GRAPHIC]An efficient protocol of dehydration was developed under microfluidic conditions. The method was applied to a multikilogram synthesis of pristane, a biologically important natural product, which is now widely used as an adjuvant for monoclonal antibody production.