Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group
Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group
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DOI：
10.1002/lary.27423
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发表时间：
2019-05-01
期刊：
影响因子：
2.6
通讯作者：
Kim, Sung Huhn
中科院分区：
文献类型：
--
作者：
Suh, Michelle J.;Jeong, Junhui;Kim, Sung Huhn
目的/假设 确定亚洲人群中双侧梅尼埃病 (MD) 患者的临床特征。研究设计横断面回顾性研究。方法 我们比较了 320 名亚洲单一种族患者的双侧 MD (BMD) 和单侧 MD (UMD) 的临床特征。人口统计变量；发病年龄；内耳功能；并存相关疾病，如前庭性偏头痛、迟发性 MD、系统性自身免疫性疾病和家族性 MD；并对预后进行分析和比较。结果BMD总体患病率为5.6%。 BMD 和 UMD 患者的平均发病年龄分别为 40.3 +/- 14.8 岁和 47.0 +/- 14.1 岁 (P = .07)。 BMD 和 UMD 患者之间的人口统计学变量没有显着差异 (P > .05)。通过听力阈值、热量测试和颈部前庭诱发肌源性电位评估的内耳功能，BMD 患者第一受累耳的内耳功能比 UMD 患者第二受累耳或受影响侧的内耳功能明显恶化 (P < .05)。在合并症中，只有迟发性MD的患病率在BMD患者中显着高于UMD患者。仅在三名 UMD 患者中发现了系统性自身免疫性疾病。 UMD 和 BMD 患者的预后没有显着差异 (P > .05)。结论 BMD 患病率较低，BMD 患者延迟性 MD 发生率较高，UMD 和 BMD 患者全身性自身免疫性疾病发生率较低，这些都是亚洲人群中的重要发现。
Objectives/Hypothesis To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population. Study Design Cross-sectional retrospective study. Methods We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Demographic variables; age of onset; inner ear function; the coexistence of related disorders such as vestibular migraine, delayed MD, systemic autoimmune diseases, and familial MD; and prognoses were analyzed and compared. Results The overall prevalence of BMD was 5.6%. The mean age of disease onset was 40.3 +/- 14.8 and 47.0 +/- 14.1 years for patients with BMD and UMD, respectively (P = .07). Demographic variables were not significantly different between patients with BMD and UMD (P > .05). Inner ear function, evaluated by hearing thresholds, caloric tests, and cervical vestibular evoked myogenic potentials, was significantly more deteriorated in the first involved ear of patients with BMD than in the second involved ear or the affected side of patients with UMD (P < .05). Among the comorbid conditions, only the prevalence of delayed MD was significantly higher in patients with BMD than in patients with UMD. Systemic autoimmune disease was found in only three patients with UMD. There was no significant prognostic difference between patients with UMD and BMD (P > .05). Conclusions A low prevalence of BMD, a higher frequency of delayed MD in BMD patients, and a low frequency of systemic autoimmune diseases in both UMD and BMD patients are significant findings in an Asian population.