Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study
Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study
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童年智力与晚年抑郁风险：纵向数据关联研究
DOI：
10.1101/2023.08.08.23293657
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ball E
中科院分区：
文献类型：
--
作者：
Ball E
研究背景：一些研究表明，儿童期智力测验分数较低与成年后抑郁症的风险较高有关。这种联系的原因尚不清楚。这项纵向数据关联研究探讨了儿童智力与儿童智力之间的关系，（11岁）和晚年抑郁症的风险（最多85岁），以及儿童时期的家庭结构和成年后的社会经济和地理因素是否可以解释这种关联。方法将1947年苏格兰精神调查中收集的智力测试分数与电子健康记录联系起来（住院和处方数据）1980年至2020年（n = 53，037），以确定抑郁症的诊断。采用混合效应考克斯回归模型探讨儿童期智力测验成绩与晚年抑郁风险的关系。分析还调整了儿童的家庭结构（家庭规模）和成年的社会经济和地理因素（卡斯泰尔斯指数，城市/农村）。在未校正的分析中（HR = 0.95，95%CI = 0.93至0.97，P < 0.001），以及校正儿童和成年期经历的因素后（HR = 0.95，95%CI = 0.91至1.00，P = 0.032），儿童期智力测试得分较高与抑郁风险降低相关。当仅使用住院数据识别抑郁症时，在未经调整的分析后，儿童智力测试得分较高与抑郁症风险降低相关（HR = 0.86，95%CI = 0.82 ~ 0.90，P < 0.001），校正儿童期和成年期危险因素后（HR = 0.94，95% CI = 0.89至0.99，P = 0.026）。有没有儿童认知测试成绩和抑郁症之间的关联时，确定抑郁症的情况下，只使用处方药data.ConclusionsThis研究提供了额外的证据表明，更高的儿童智力预测降低风险的晚年抑郁症只有当抑郁症是基于入院记录进行评估。儿童期的家庭结构和成年期的社会经济和地理因素似乎不是实质性的混杂因素。
BackgroundLower childhood intelligence test scores are reported in some studies to be associated with higher risk of depression in adulthood. The reasons for the association are unclear. This longitudinal data-linkage study explored the relationship between childhood intelligence (at age ∼11) and risk of depression in later-life (up to age ∼85), and whether childhood family structure and adulthood socio-economic and geographical factors accounted for some of this association.MethodsIntelligence test scores collected in the Scottish Mental Survey 1947 were linked to electronic health records (hospital admissions and prescribing data) between 1980 and 2020 (n = 53,037), to identify diagnoses of depression. Mixed-effect Cox regression models were used to explore the relationship between childhood intelligence test scores and risk of depression in later-life. Analyses were also adjusted for childhood family structure (size of family) and adulthood socio-economic and geographical factors (Carstairs index, urban/rural).ResultsTwenty-seven percent of participants were diagnosed with depression during follow-up (n = 14,063/53,037). Greater childhood intelligence test scores were associated with a reduced risk of depression in an unadjusted analysis (HR = 0.95, 95% CI = 0.93 to 0.97, P < 0.001), and after adjustment for factors experienced in childhood and adulthood (HR = 0.95, 95% CI = 0.91 to 1.00, P = 0.032). When identifying depression using only hospital admissions data, greater childhood intelligence test scores were associated with a reduced risk of depression following unadjusted analysis (HR = 0.86, 95% CI = 0.82 to 0.90, P < 0.001), and after adjusting for risk factors in childhood and adulthood (HR = 0.94, 95% CI = 0.89 to 0.99, P = 0.026). There was no association between childhood cognitive test scores and depression when identifying cases of depression using only prescribed drugs data.ConclusionsThis study provides additional evidence suggesting that higher childhood intelligence predicts reduced risk of later-life depression only when depression is assessed based on hospital admission records. Childhood family structure and adulthood socio-economic and geographical factors did not seem to be substantial confounders.
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影响因子：
2.6
作者：
S. P. Akpabio
通讯作者：
S. P. Akpabio
影响因子：
6.6
作者：
Christensen, Gunhild Tidemann;Rozing, Maarten Pieter;Osler, Merete
通讯作者：
Osler, Merete
影响因子：
6.9
作者：
Iveson, Matthew H.;Taylor, Adele;Harris, Sarah E.;Deary, Ian J.;McIntosh, Andrew M.
通讯作者：
McIntosh, Andrew M.
探索使用信息方法的价值来确定研究的优先顺序，以解决詹姆斯·林德联盟优先确定合作伙伴确定的治疗不确定性。
影响因子：
4.5
作者：
T. Sach;E. McManus
通讯作者：
E. McManus
苏格兰政府
DOI：
--
发表时间：
1998
期刊：
A Diverse Assembly
影响因子：
--
作者：
Elli Kontorravdis
通讯作者：
Elli Kontorravdis